pyrazinamide
CLINICAL USE
Antimicrobial agent for tuberculosis
DOSE IN NORMAL RENAL FUNCTION
1.5–2 g per day
PHARMACOKINETICS
Molecular weight                           :123.1 %Protein binding                           :10 %Excreted unchanged in urine     : 4 Volume of distribution (L/kg)       :0.75–1.3half-life – normal/ESRD (hrs)      :9–10/26 DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Use 50–100% of dose DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Not dialysed. Dose as in GFR <10 mL/min HD                     :50–100% dialysed. Dose as in GFR <10 mL/min or 25–30 mg/kg post dialysis1HDF/high flux   :Dialysed. Dose as in GFR <10           : mL/min or 25–30 mg/kg post dialysis1CAV/VVHD      :Unknown dialysability. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsCiclosporin: on limited evidence, pyrazinamide appears to reduce ciclosporin levels ADMINISTRATION
Reconstition
– Route
Oral Rate of Administration
–Comments
– OTHER INFORMATION
Available from IDIS on a named patient basis. Can precipitate gout as impairs urate excretion
See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
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