moxonidine
CLINICAL USE
Antihypertensive agent (centrally acting agonist at I1 receptor, imidazoline and alpha2 adrenoceptors)
DOSE IN NORMAL RENAL FUNCTION
200–600 mcg daily(Doses >400 mcg should be in 2 divided doses)
PHARMACOKINETICS
Molecular weight                           :241.7 %Protein binding                           :7 %Excreted unchanged in urine     : 50–75 Volume of distribution (L/kg)       :1.8half-life – normal/ESRD (hrs)      :2–3/6.9 +/–3.7 DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
30–60 Dose as in normal renal function 10–30 Dose as in normal renal function <10           : Dose as in normal renal function DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Probably dialysed. Dose as in normal renal function HD                     :Probably dialysed. Dose as in normal renal functionHDF/high flux   :Probably dialysed. Dose as in normal renal functionCAV/VVHD      :Probably dialysed. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsNone known ADMINISTRATION
Reconstition
– Route
Oral Rate of Administration
–Comments
– OTHER INFORMATION
In moderately impaired renal function (GFR=30–60 mL/min) AUC is increased by 85% and clearance decreased by 52%; therefore, monitor patient closely .Anecdotal evidence suggests that moxonidine can be used safely at standard doses in patients with all degrees of renal impairment
One paper suggests that moxonidine can be used in patients with severe renal failure, at a dose of 300 mcg daily.
See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
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