movicol

CLINICAL USE

Laxative

DOSE IN NORMAL RENAL FUNCTION

1–3 sachets daily in divided doses in 125 mL of waterMaintenance: 1–2 sachets daily

PHARMACOKINETICS

Molecular weight :3350

%Protein binding :Not absorbed

%Excreted unchanged in urine : Not absorbed

Volume of distribution (L/kg) :Not absorbed

half-life – normal/ESRD (hrs) :Not absorbed

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Not dialysed. Dose as in normal renal function

HD :Not dialysed. Dose as in normal renal function

HDF/high flux :Not dialysed. Dose as in normal renal function

CAV/VVHD :Not dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

None known

ADMINISTRATION

Reconstition

–

Route

Oral

Rate of Administration

–

Comments

–

OTHER INFORMATION

Movicol contains polyethylene glycol, sodium chloride, sodium bicarbonate and potassium chlorideElectrolyte content of a sachet when made up with 125 mL water is:Sodium 65 mmol/L —Chloride 53 mmol/L —Potassium 5.4 mmol/L —Bicarbonate 17 mmol/L —Sachets are formulated to ensure that there is virtually no net gain or loss of sodium, potassium or waterMovicol (active ingredient is the osmotic laxative polyethylene glycol).

See how to identify renal failure stages according to GFR calculation

See how to diagnose irreversible renal disease

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