nicorandil
nicorandil.JPG

CLINICAL USE

Prevention and treatment of chronic stable angina

DOSE IN NORMAL RENAL FUNCTION

5–30 mg twice daily

PHARMACOKINETICS

  • Molecular weight                           :211.2
  • %Protein binding                           :Slightly
  • %Excreted unchanged in urine     : 1
  • Volume of distribution (L/kg)       :No data
  • half-life – normal/ESRD (hrs)      :1/Unchanged

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Unknown dialysability. Dose as in normal renal function
  • HD                     :Unknown dialysability. Dose as in normal renal function
  • HDF/high flux   :Unknown dialysability. Dose as in normal renal function
  • CAV/VVHD      :Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugsSildenafil, tadalafil and vardenafil: enhanced hypotensive effect, avoid concomitant use

    ADMINISTRATION

    Reconstition

    Route

    Oral

    Rate of Administration

    Comments





    See how to identify renal failure stages according to GFR calculation

    See how to diagnose irreversible renal disease

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