nicorandil
CLINICAL USE
Prevention and treatment of chronic stable angina
DOSE IN NORMAL RENAL FUNCTION
5–30 mg twice daily
PHARMACOKINETICS
Molecular weight                           :211.2 %Protein binding                           :Slightly %Excreted unchanged in urine     : 1 Volume of distribution (L/kg)       :No datahalf-life – normal/ESRD (hrs)      :1/Unchanged DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Dose as in normal renal function DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unknown dialysability. Dose as in normal renal function HD                     :Unknown dialysability. Dose as in normal renal functionHDF/high flux   :Unknown dialysability. Dose as in normal renal functionCAV/VVHD      :Unknown dialysability. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsSildenafil, tadalafil and vardenafil: enhanced hypotensive effect, avoid concomitant use ADMINISTRATION
Reconstition
– Route
Oral Rate of Administration
–Comments
See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
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