HEALTHY LIFESTYLE




dopexamine hydrochloride
dopexamine hydrochloride.JPG

dopexamine hydrochloride

CLINICAL USE

Inotropic support in exacerbations of heart failure and heart failure associated with cardiac surgery

DOSE IN NORMAL RENAL FUNCTION

IV infusion

: 0.5 –1 mcg/kg/minute and then in increments (0.5–1 micrograms/kg/minute) up to 6 micrograms/kg/minute at not less than 15 minute intervals

PHARMACOKINETICS

  • Molecular weight                           :429.4
  • %Protein binding                           :No data
  • %Excreted unchanged in urine     : 10
  • Volume of distribution (L/kg)       :0.45
  • half-life – normal/ESRD (hrs)      :6–11 minutes/–

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function and adjust to response
  • 10 to 20     : Dose as in normal renal function and adjust to response
  • <10           : Dose as in normal renal function and adjust to response

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Unknown dialysability. Dose as in normal renal function
  • HD                     :Unknown dialysability. Dose as in normal renal function
  • HDF/high flux   :Unknown dialysability. Dose as in normal renal function
  • CAV/VVHD      :Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs
  • Antidepressants: risk of hypertensive crisis with MAOIs and moclobemide
  • Beta-blockers: risk of severe hypertension
  • Sympathomimetics: effects of adrenaline and noradrenaline possibly enhanced

    ADMINISTRATION

    Reconstition

    Route

    By intravenous infusion into a central or large peripheral vein

    Rate of Administration

    See dosage instructions

    Comments

    IV infusion

    of 400 or 800 micrograms/mL in glucose 5% or sodium chloride 0.9%Peripheral administration: concentration of infusion solution must not exceed 1 mg/mL
  • Central administration: concentration not >4 mg/mLRate of administration and duration of therapy should be adjusted according to the patient’s response as determined by heart rate and rhythm, blood pressure, urine flow and measurement of cardiac output

    OTHER INFORMATION

    Avoid abrupt withdrawal
  • other drugs