Zopiclone
CLINICAL USE
Hypnotic
DOSE IN NORMAL RENAL FUNCTION
3.75–7.5 mg at night
PHARMACOKINETICS
Molecular weight : 388.8 %Protein binding : 45–80 %Excreted unchanged in urine : <5 Volume of distribution (L/kg) : 91.8–104.6 litres half-life – normal/ESRD (hrs) : 3.5–6.5/Unchanged DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50 : Dose as in normal renal function 10 to 20 : Dose as in normal renal function <10 : Start with lower dose DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD : Dialysed. Dose as in GFR <10 mL/min HD : Dialysed. Dose as in GFR <10 mL/min HDF/high flux : Dialysed. Dose as in GFR <10 mL/min CAV/VVHD : Dialysed. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs Antibacterials: metabolism inhibited by erythromycin and quinupristin/ dalfopristin; concentration significantly reduced by rifampicin Antipsychotics: enhanced sedative effects Antivirals: concentration possibly increased by ritonavir ADMINISTRATION
Reconstition
– Route
Oral Rate of Administration
– Comments
– OTHER INFORMATION
It is recommended that elderly patients and those with severe renal disease should start treatment with 3.75 mg; however, accumulation has not been observed .
See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
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