Paracetamol
CLINICAL USE
Analgesia and antipyretic
DOSE IN NORMAL RENAL FUNCTION
500 mg – 1 g every 4–6 hours(IV: if <50 kg, dose is 15 mg/kg)
PHARMACOKINETICS
Molecular weight                           :151.2 %Protein binding                           :20–30 %Excreted unchanged in urine     : <5 Volume of distribution (L/kg)       :1–2half-life – normal/ESRD (hrs)      :1–4/Unchanged DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : 500 mg – 1 g every 6–8 hours DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Not dialysed. Dose as in GFR <10 mL/min HD                     :Dialysed. Dose as in GFR <10           : mL/min HDF/high flux   :Dialysed. Dose as in GFR <10           : mL/min CAV/VVHD      :Unknown dialysability. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsNone known ADMINISTRATION
Reconstition
– Route
Oral, rectal, IV Rate of Administration
15 minutes Comments
– OTHER INFORMATION
Beware sodium content of soluble tablets (1 tablet ≡ 18.6 mmol sodium)Nephrotoxic in overdose due to a reactive alkylating metaboliteMetabolites may accumulate in CKD 5; normal doses are used in CKD 5IV preparation starts working within 5 to 10 minutes with peak activity after 60 minutes.
See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
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