Methyldopa
Methyldopa.JPG

CLINICAL USE

Hypertension

DOSE IN NORMAL RENAL FUNCTION

250 mg 2–3 times a day, increasing to a maximum dose of 3 g daily

PHARMACOKINETICS

  • Molecular weight                           :238.2
  • %Protein binding                           :<15
  • %Excreted unchanged in urine     : 25–40
  • Volume of distribution (L/kg)       :0.5
  • half-life – normal/ESRD (hrs)      :1.6–2/6–16

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function and adjust according to response
  • 10 to 20     : Dose as in normal renal function and adjust according to response
  • <10           : Dose as in normal renal function and adjust according to response

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Dialysed. Dose as in GFR
  • <10           : mL/min
  • HD                     :Dialysed. Dose as in GFR
  • <10           : mL/min
  • HDF/high flux   :Dialysed. Dose as in GFR
  • <10           : mL/min
  • CAV/VVHD      :Probably dialysed. Dose as in GFR 10 to 20 mL/min

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs
  • Anaesthetics: enhanced hypotensive effect
  • Antidepressants: avoid concomitant use with MAOIs
  • Lithium: neurotoxicity (without increased plasma-lithium concentrations)Salbutamol: acute hypotension reported with salbutamol infusions

    ADMINISTRATION

    Reconstition

    Route

    Oral

    Rate of Administration

    Comments

    OTHER INFORMATION

    Active metabolites with long half-life Interferes with serum creatinine measurementOrthostatic hypotension more common in renally impaired patients.



    See how to identify renal failure stages according to GFR calculation

    See how to diagnose irreversible renal disease

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