Flucloxacillin

CLINICAL USE

Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION

Oral: 250–500 mg every 6 hours IV: 250 mg – 2 g every 6 hours IM: 250–500 mg every 6 hours Endocarditis: maximum 2 g every 4 hours if > 85 kgOsteomyelitis: maximum 8 g daily in divided doses

PHARMACOKINETICS

Molecular weight :453.9

%Protein binding :95

%Excreted unchanged in urine : 66–76

Volume of distribution (L/kg) :0.13

half-life – normal/ESRD (hrs) :53–60 minutes/ 135–173 minutes

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function up to a total daily dose of 4 g

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Not dialysed. Dose as in GFR <10 mL/min

HD :Not dialysed. Dose as in GFR <10 mL/min

HDF/high flux :Not dialysed. Dose as in GFR <10 mL/min

CAV/VVHD :Not dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsReduces excretion of methotrexate

ADMINISTRATION

Reconstition

IV: 250 mg and 500 mg in 5–10 mL water for injection; 1 g in 15–20 mL water for injectionIM: 250 mg in 1.5 mL water for injection; 500 mg in 2 mL water for injection

Route

IV, IM, oral

Rate of Administration

Bolus: 3–4 minutes Infusion: 30–60 minutes

Comments

Compatible with various infusion fluids

OTHER INFORMATION

Monitor urine for protein at high doses Sodium content of injection: 2.26 mmol/g Monitor liver function tests in hypoalbuminaemic patients receiving high doses of flucloxacillin

See how to identify renal failure stages according to GFR calculation

See how to diagnose irreversible renal disease

Home