Clofazimine

CLINICAL USE

Treatment of leprosy

DOSE IN NORMAL RENAL FUNCTION

Multibacillary leprosy: 300 mg once monthly (supervised) or 50 mg daily or 100 mg alternate days (unsupervised)Lepromatous lepra reactions: 300 mg daily

PHARMACOKINETICS

Molecular weight :473.4

%Protein binding :Low1

%Excreted unchanged in urine : <1

Volume of distribution (L/kg) :High1

half-life – normal/ESRD (hrs) :10–70 days/Unchanged1

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Not dialysed. Dose as in normal renal function

HD :Not dialysed. Dose as in normal renal function

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Unknown dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsNone known

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

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Comments

OTHER INFORMATION

In the sunlight a red/brown discolouration may appear on the skinSecretions may also become a red/brown colourAvailable on a named patient basis

See how to identify renal failure stages according to GFR calculation

See how to diagnose irreversible renal disease

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