MEROPENEM

Brand Name & Strength

DBL Meropenem 500 mg & 1 g

Reconstitution

Reconstitute each 500 mg of Meropenem with 10 ml of WFI

Further Dilution

IV infusion

Further dilute with 50 – 200 ml diluent (Concentration: 1 – 20 mg/ml)

Diluent

NS, D5

Administration & Infusion rate

Slow IV Administer over 3 – 5 min

IV infusion

Administer over 15 – 30 min Administer over 4 hr (extended infusion)

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

8 hr 24 hr

After dilution

8 hr (NS), 3 hr (D5) 24 hr (NS), 14 hr (D5)

Remarks

Extended infusion has been shown to improve the time the free drug remains above MIC that predicts the killing characteristic of the antibiotic