LEUCOVORIN CALCIUM

Brand Name & Strength

Leucovorin Calcium Injection USP 3 mg/ml, 50 mg/5 ml

Reconstitution

Not required

Further Dilution

IV infusion

Dilute the required dose in 100 – 250 ml diluent

Diluent

NS, D5, D10, NSD10, Ringers solution

Administration & Infusion rate

IV bolus

, Slow IV, IM

IV infusion

Administer over 15 min to 2 hours (rate not to exceed 160 mg/min)

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

- -

After dilution

24 hr (NS, Ringer’s), 12 hr (D5, D10), 6 hr (NSD10) -

Remarks

Leucovorin is harmful or fatal if given intrathecally

Do not administer IV solutions at a rate > 160 mg/min due to the calcium content of the solution