IMIPENEM CILASTATIN

IMIPENEM CILASTATIN

Brand Name & Strength

Tienam® 500 mg

Reconstitution

Reconstitute with 10 ml diluent , repeat with an additional 10 ml of diluent to ensure complete transfer of vial contents.

Further Dilution

Dilute with 100 ml of diluent (max concentration: 5 mg/ml)

Diluent

D5, NS

Administration & Infusion rate

IV infusion

  • Dose ≥ 750 mg: Administered at over 40 – 60 min
  • Dose ≤ 500 mg: Administered at over 20 – 30 min

    Storage & Stability

    RT

    (<25 oC)

    Fridge

    (2 – 8 oC)

    After Reconstitution

    -

    After dilution

    4 hr 24 hr

    Remarks

  • Administer only as slow

    IV infusion

    . Do not give by direct IV injection.
  • To slow infusion rate if patient experienced nausea, vomiting, dizziness, or sweating.