BENZYLPENICILLIN

Brand Name & Strength

Benzyl Penicillin for Injection BP 1 MIU (600 mg) and 5 MIU (3 g)

Reconstitution

Reconstitute 1 MIU vial with 2 ml or more WFI immediately before use

Reconstitute 5 MIU vial with 10 ml or more WFI immediately before use

Further Dilution

IV infusion

Further dilute in 50 – 100 ml diluent Continuous

IV infusion

Further dilute in 1000 – 2000 ml diluent

Diluent

NS, D5

Administration & Infusion rate

At upper outer quadrant of the buttock

IV infusion

Administer over 30 min – 1 hr or 1 – 2 hr Continuous

IV infusion

Administer over 24 hr

Preferred for administration of large doses

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

2 days 6 days

After dilution

- -

Remarks

Too rapid infusion may cause electrolyte imbalance or seizures

Do not use plastic containers in series connections as it could result in air embolism due to residual air being drawn from primary container before administration of fluid from secondary ends

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