pseudoephedrine hydrochloride

Nasal decongestant

60 mg 4 times a day

Molecular weight :201.7

%Protein binding :No data

%Excreted unchanged in urine : 90–98

Volume of distribution (L/kg) :2–3

half-life – normal/ESRD (hrs) :5.5 (depends on pH of urine)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function. Use with caution

<10 : Dose as in normal renal function. Use with caution

CAPD :Unlikely dialysability. Dose as in normal renal function

HD :Not dialysed. Dose as in normal renal function

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Unknown dialysability. Dose as in normal renal function

Potentially hazardous interactions with other drugsAdrenergic neurone blockers: antagonise hypotensive effect of adrenergic neurone blockers

Antibacterials: risk of hypertensive crisis with linezolid

Antidepressants: risk of hypertensive crisis with MAOIs and moclobemide

Dopaminergics: avoid concomitant use with rasagiline

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Oral

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5–20% is removed by haemodialysis Increased risk of developing hypertension in patients with GFR<20 mL/min