promethazine hydrochloride

Antihistamine

Oral: 25 mg at night increased to twice daily, or

10 to 20 : mg 2–3 times a daySlow IV/IM: 25–100 mg

Molecular weight :320.9

%Protein binding :76–93

%Excreted unchanged in urine : 0

Volume of distribution (L/kg) :13.5

half-life – normal/ESRD (hrs) :5–14/–

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

CAPD :Unknown dialysability. Dose as in normal renal function

HD :Not dialysed. Dose as in normal renal function

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Unknown dialysability. Dose as in normal renal function

Potentially hazardous interactions with other drugs

None known

–

IV, IM, oral

Bolus over 3–5 minutes

Administer in 10 mL water for injection for slow IV injection (2.5 mg/mL)

Excessive sedation may occur in CKD 5