penicillin V

Antibacterial agent

500–1000 mg every 6 hours

Molecular weight :350.4

%Protein binding :80

%Excreted unchanged in urine : 60–90

Volume of distribution (L/kg) :0.5

half-life – normal/ESRD (hrs) :0.5–1/4

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

CAPD :Not dialysed. Dose as normal renal function

HD :Dialysed. Dose as in normal renal function

HDF/high flux :Dialysed. Dose as in normal renal function

CAV/VVHD :Dialysed. Dose as in normal renal function

Potentially hazardous interactions with other drugsReduces excretion of methotrexate

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Oral

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Renal failure prolongs half-life of phenoxymethylpenicillin, but as it has a wide therapeutic index no dose adjustment is necessary