metoclopramide hydrochloride

Nausea and vomiting

10 mg 3 times a day. Use in patients under 20 years should be restricted

Molecular weight :354.3

%Protein binding :13–22

%Excreted unchanged in urine : 20–30

Volume of distribution (L/kg) :3.5

half-life – normal/ESRD (hrs) :4–6/15

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

CAPD :Not dialysed. Dose as in normal renal function

HD :Dialysed. Dose as in normal renal function

HDF/high flux :Dialysed. Dose as in normal renal function

CAV/VVHD :Dialysed. Dose as in normal renal function

Potentially hazardous interactions with other drugs

Ciclosporin: increased ciclosporin blood levels

–

Oral, IV, IM

1–2 minutes

–

Increased risk of extrapyramidal reactions in severe renal impairmentCan be used for hiccups at a dose of 10 mg 3 times a day