Propylthiouracil

Hyperthyroidism

Initially: 200–400 mg dailyMaintenance dose: 50–150 mg daily

Molecular weight :170.2

%Protein binding :80

%Excreted unchanged in urine : <2

Volume of distribution (L/kg) :0.3–0.4

half-life – normal/ESRD (hrs) :1–2/8.5

20 to 50 : Dose as in normal renal function

10 to 20 : 75% of normal dose and titrate to response

<10 : 50% of normal dose and titrate to response

CAPD :Unknown dialysability. Dose as in GFR <10 mL/min

HD :Not dialysed. Dose as in GFR <10 mL/min

HDF/high flux :Unknown dialysability. Dose as in GFR <10 mL/min

CAV/VVHD :Unknown dialysability. Dose as in GFR 10 to 20 mL/min

Potentially hazardous interactions with other drugs

None known

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Oral

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Renally impaired patients are at a greater risk of cardiotoxicity and leucopenia.