Pramipexole

CLINICAL USE

Parkinson’s disease Symptomatic treatment of restless legs

DOSE IN NORMAL RENAL FUNCTION

Parkinson’s disease: 88 – 1100 mcg 3 times a dayRestless legs: 88–540 mcg taken 2–3 hours before bedtime

PHARMACOKINETICS

Molecular weight :302.3 (as hydrochloride)

%Protein binding :<20

%Excreted unchanged in urine : <90

Volume of distribution (L/kg) :400–500 litres

half-life – normal/ESRD (hrs) :8–14/36

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Initially 88 mcg twice daily and titrate slowly

10 to 20 : Initially 88 mcg once daily and titrate slowly

<10 : Initially 88 mcg once daily and titrate slowly

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Not dialysed. Dose as in GFR <10 mL/min

HD :Not dialysed. Dose as in GFR <10 mL/min

HDF/high flux :Unknown dialysability. Dose as in GFR <10 mL/min

CAV/VVHD :Not dialysed. Dose as in GFR=10–20 mL/min

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsAvoid concomitant use with antipsychotics

ADMINISTRATION

Reconstition

–

Route

Oral

Rate of Administration

–

Comments

–

OTHER INFORMATION

88 mcg of base ≡ 125 mcg of salt, 180 mcg ≡ 250 mcg, 350 mcg ≡ 500 mcg, 700 mcg ≡ 1 mg, 1.1 mg ≡ 1.5 mgLess than 9% of dose is removed by haemodialysisDrowsiness is a common side effect especially at higher dosesFor restless legs, dose as in normal renal function.

See how to identify renal failure stages according to GFR calculation

See how to diagnose irreversible renal disease

Home