Pizotifen

Prophylactic treatment of vascular headaches including migraine

1.5 mg at night or 500 mcg 3 times a day adjusted according to responseMaximum single dose: 3 mgMaximum daily dose: 4.5 mg

Molecular weight :429.5 (as malate)

%Protein binding :>90

%Excreted unchanged in urine : <1 (55% as metabolites)

Volume of distribution (L/kg) :6–8

half-life – normal/ESRD (hrs) :1 (metabolite 23 hours)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose reduction may be required. Monitor for drowsiness

CAPD :Unlikely to be dialysed. Dose as in GFR <10 mL/min

HD :Unlikely to be dialysed. Dose as in GFR <10 mL/min

HDF/high flux :Unknown dialysability. Dose as in GFR <10 mL/min

CAV/VVHD :Unlikely to be dialysed. Dose as in normal renal function

Potentially hazardous interactions with other drugsAdrenergic neurone blockers: pizotifen antagonises hypotensive effect

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Oral

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Use with caution in people with a predisposition for urinary retention or closed angle glaucomaPizotifen has appetite stimulating properties.