Piperazine

CLINICAL USE

Treatment of threadworm and roundworm infections

DOSE IN NORMAL RENAL FUNCTION

Threadworm: 4 g sachet stirred into a glass of milk or water and drunk immediately; repeat after 14 daysRoundworms: 4 g sachet stirred into a glass of milk or water and drunk immediately; repeat at monthly intervals for up to 3 months if re-infection risk

PHARMACOKINETICS

Molecular weight :86.14 (202.1 as phosphate); (642.7 as citrate)

%Protein binding :No data

%Excreted unchanged in urine : 5–30

Volume of distribution (L/kg) :No data

half-life – normal/ESRD (hrs) :No data

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function but avoid repeated administration

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Unknown dialysability. Dose as in GFR <10 mL/min

HD :Unknown dialysability. Dose as in GFR <10 mL/min

HDF/high flux :Unknown dialysability. Dose as in GFR <10 mL/min

CAV/VVHD :Unknown dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsPyrantel: antagonises effect of piperazine

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

–

Comments

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OTHER INFORMATION

May accumulate in severe renal impairment causing neurotoxicityActs within the lumen of the gastrointestinal tract which is independent of any systemic absorption.

See how to identify renal failure stages according to GFR calculation

See how to diagnose irreversible renal disease

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