Pentostatin
CLINICAL USE
Antineoplastic agent used in hairy cell leukaemia
DOSE IN NORMAL RENAL FUNCTION
4 mg/m2 every other week
PHARMACOKINETICS
Molecular weight                           :268.3 %Protein binding                           :4 %Excreted unchanged in urine     : 50–96 Volume of distribution (L/kg)       :36.1 litreshalf-life – normal/ESRD (hrs)      :2.6–10/18 DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
50–60 50% of dose. See ‘Other Information’10–50 See ‘Other Information’ <10           : See ‘Other Information’ DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unknown dialysability. Dose as in GFR <10 mL/min HD                     :Unknown dialysability. Dose as in GFR <10 mL/minHDF/high flux   :Likely dialysability. Dose as in GFR <10 mL/minCAV/VVHD      :Unknown dialysability. Dose as in GFR=10–50 mL/min IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsAntipsychotics: avoid concomitant use with clozapine (increased risk of agranulocytosis)Cytotoxics: increased risk of toxicity with high-dose cyclophosphamide – avoid concomitant use; increased pulmonary toxicity with fludarabine (unacceptably high incidence of fatalities) ADMINISTRATION
Reconstition
5 mL water for injections Route
IV bolus or infusion Rate of Administration
20–30 minutes Comments
Add to 25–50 mL glucose 5% or sodium chloride 0.9% (final concentration 180–330 mcg/mL) OTHER INFORMATION
Only a small amount is metabolised. It is primarily excreted unchanged by the kidneys (30–90% excreted by kidneys within 24 hours)Patients with CKD are at a greater risk of toxicity with pentostatin
See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
Home