Pentostatin
Pentostatin.JPG

CLINICAL USE

Antineoplastic agent used in hairy cell leukaemia

DOSE IN NORMAL RENAL FUNCTION

4 mg/m2 every other week

PHARMACOKINETICS

  • Molecular weight                           :268.3
  • %Protein binding                           :4
  • %Excreted unchanged in urine     : 50–96
  • Volume of distribution (L/kg)       :36.1 litres
  • half-life – normal/ESRD (hrs)      :2.6–10/18

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

    50–60 50% of dose. See ‘Other Information’10–50 See ‘Other Information’
  • <10           : See ‘Other Information’

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Unknown dialysability. Dose as in GFR <10 mL/min
  • HD                     :Unknown dialysability. Dose as in GFR <10 mL/min
  • HDF/high flux   :Likely dialysability. Dose as in GFR <10 mL/min
  • CAV/VVHD      :Unknown dialysability. Dose as in GFR=10–50 mL/min

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs
  • Antipsychotics: avoid concomitant use with clozapine (increased risk of agranulocytosis)Cytotoxics: increased risk of toxicity with high-dose cyclophosphamide – avoid concomitant use; increased pulmonary toxicity with fludarabine (unacceptably high incidence of fatalities)

    ADMINISTRATION

    Reconstition

    5 mL water for injections

    Route

    IV bolus or infusion

    Rate of Administration

    20–30 minutes

    Comments

    Add to 25–50 mL glucose 5% or sodium chloride 0.9% (final concentration 180–330 mcg/mL)

    OTHER INFORMATION

    Only a small amount is metabolised. It is primarily excreted unchanged by the kidneys (30–90% excreted by kidneys within 24 hours)Patients with CKD are at a greater risk of toxicity with pentostatin



    See how to identify renal failure stages according to GFR calculation

    See how to diagnose irreversible renal disease

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