Moclobemide

CLINICAL USE

Reversible MAOI:Depression Social phobia

DOSE IN NORMAL RENAL FUNCTION

Depression: 150–600 mg daily in divided dosesSocial phobia: 300 mg twice daily

PHARMACOKINETICS

Molecular weight :268.7

%Protein binding :50

%Excreted unchanged in urine : <1

Volume of distribution (L/kg) :1

half-life – normal/ESRD (hrs) :2–4/unchanged

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Likely dialysability. Dose as in normal renal function

HD :Likely dialysability. Dose as in normal renal function

HDF/high flux :Likely dialysability. Dose as in normal renal function

CAV/VVHD :Likely dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Analgesics: possible CNS excitation or depression with dextromethorphan or pethidine – avoid concomitant use; possible CNS excitation or depression with opioid analgesics

Antidepressants: avoid concomitant use; possible increased serotonergic effects with duloxetine

Antimalarials: avoid concomitant use with artemether/lumefantrineBupropion: avoid concomitant use

Dopaminergics: use with caution with entacapone; increased side effects with levodopa; avoid concomitant use with selegiline5HT 1 agonists: increased CNS toxicity with rizatriptan and sumatriptan – avoid concomitant use; increased CNS toxicity with zolmitriptan – reduce zolmitriptan dose

Sibutramine: increased CNS toxicity – avoid concomitant use

Sympathomimetics: risk of hypertensive crisis

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

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Comments

Take after food

OTHER INFORMATION

Hyponatraemia has been reported (especially in elderly patients) due to inappropriate secretion of antidiuretic hormone.

See how to identify renal failure stages according to GFR calculation

See how to diagnose irreversible renal disease

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