Liothyronine
Liothyronine
CLINICAL USE
Hypothyroidism
DOSE IN NORMAL RENAL FUNCTION
Oral:
10 to 20     : micrograms daily, increased to 60 micrograms in 2–3 divided dosesIV: 5–20 micrograms every 4–12 hours, or 50 micrograms initially then 25 micrograms every 8 hours, reducing to 25 micrograms twice a day PHARMACOKINETICS
Molecular weight                           :673 %Protein binding                           :<99 %Excreted unchanged in urine     : 2.5 Volume of distribution (L/kg)       :0.1–0.2half-life – normal/ESRD (hrs)      :24–48/– DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Dose as in normal renal function DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Not dialysed. Dose as in normal renal function HD                     :Not dialysed. Dose as in normal renal function HDF/high flux   :Not dialysed. Dose as in normal renal functionCAV/VVHD      :Not dialysed. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsAnticoagulants: effect of coumarins and phenindione enhanced ADMINISTRATION
Reconstition
Dissolve with 1–2 mL water for injection Route
IV, oral Rate of Administration
Slow bolus Comments
Alkaline solution – may cause irritation if given IM OTHER INFORMATION
20 mcg of liothyronine is equivalent to 100 mcg of levothyroxineProtein-losing states, such as nephrotic syndrome, will result in a decrease in total T3 and T4Thyroxine (T4) is the drug of choice in hypothyroidism, but T3 can be useful due to its rapid onset of actionElderly patients should receive smaller initial doses
See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
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