Hypothyroidism

25–300 micrograms daily depending on thyroid hormone levels

Molecular weight :798.9

%Protein binding :99.97

%Excreted unchanged in urine : 30–55

Volume of distribution (L/kg) :8.7–9.7

half-life – normal/ESRD (hrs) :6–7 days/ Unchanged

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

CAPD :Not dialysed. Dose as in normal renal function

HD :Not dialysed. Dose as in normal renal function

HDF/high flux :Not dialysed. Dose as in normal renal function

CAV/VVHD :Not dialysed. Dose as in normal renal function

Potentially hazardous interactions with other drugs

Anticoagulants: effect of coumarins and phenindione enhanced

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Oral

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Uraemic toxins may result in inhibition of the enzyme associated with conversion of L-thyroxine to liothyronine