Mild to moderate dementia in Alzheimer’s disease

4–12 mg twice daily

Molecular weight :368.3 (as hydrobromide)

%Protein binding :18

%Excreted unchanged in urine : 18–22

Volume of distribution (L/kg) :175 litres

half-life – normal/ESRD (hrs) :7–8 (XL: 8–10)/Increased

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function but start with lower doses

CAPD :Dialysed. Dose as in GFR

<10 : mL/min

HD :Dialysed. Dose as in GFR

<10 : mL/min

HDF/high flux :Dialysed. Dose as in GFR

<10 : mL/min

CAV/VVHD :Dialysed. Dose as in normal renal function

Potentially hazardous interactions with other drugs

Antibacterials: erythromycin increases plasma concentration of galantamine

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Oral

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