Short-term treatment of blood loss in menorrhagiaProphylaxis of surgical bleeding (unlicensed)

Menorrhagia: 500 mg 4 times a day during menstruationSurgical bleeding: 1–1.5 g daily or 250– 500 mg every 4–6 hours

Molecular weight :263.3

%Protein binding :>90

%Excreted unchanged in urine : 72–80

Volume of distribution (L/kg) :No data

half-life – normal/ESRD (hrs) :3.7–8

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

CAPD :Unlikely to be dialysed. Dose as in normal renal function

HD :Unlikely to be dialysed. Dose as in normal renal function

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Unlikely to be dialysed. Dose as in normal renal function

Potentially hazardous interactions with other drugs

None known

–

Oral

–

–