Anxiety (short-term use)

Alcohol withdrawal

Anxiety: 30–100 mg daily in divided doses

Alcohol withdrawal: 10–50 mg 4 times a day, reducing gradually

Molecular weight :336.2

%Protein binding :96

%Excreted unchanged in urine : 1–2

Volume of distribution (L/kg) :0.3–0.5

half-life – normal/ESRD (hrs) :6–30/Unchanged

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : 50% of normal dose

CAPD :Unlikely to be dialysed. Dose as in GFR <10 mL/min

HD :Not dialysed. Dose as in GFR <10 mL/min

HDF/high flux :Unknown dialysability. Dose as in GFR <10 mL/min

CAV/VVHD :Unknown dialysability. Dose as in normal renal function

Potentially hazardous interactions with other drugs

Antibacterials: metabolism possibly increased by rifampicinA

ntipsychotics: enhanced sedative effects

Antivirals:

concentration possibly increased by ritonavir

Sodium oxybate: enhanced effects of sodium oxybate – avoid

Ulcer-healing drugs: metabolism inhibited by cimetidine

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Oral

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Active metabolite (desmethyldiazepam) has a half-life of a few days