Calcium resonium
Calcium resonium
CLINICAL USE
Hyperkalaemia (not for emergency treatment)
DOSE IN NORMAL RENAL FUNCTION
Oral: 15 g 3–4 times daily in water
PR: 30 g in methylcellulose solution retained for 9 hours PHARMACOKINETICS
Molecular weight                           :– %Protein binding                           :– %Excreted unchanged in urine     : 0 Volume of distribution (L/kg)       :–half-life – normal/ESRD (hrs)      :– DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50     : Dose as in normal renal function. Titrate to response 10 to 20     : Dose as in normal renal function. Titrate to response <10           : Dose as in normal renal function. Titrate to response DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Not dialysed. Dose as in normal renal function HD                     :Not dialysed. Dose as in normal renal functionHDF/high flux   :Not dialysed. Dose as in normal renal functionCAV/VVHD      :Not dialysed. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsNone known ADMINISTRATION
Reconstition
PR: Mix with methylcellulose solution 2% Oral: Mix with a little water, sweetened if preferred Route
Oral or PR Rate of Administration
– Comments
– OTHER INFORMATION
Ensure a regular laxative is prescribed – can mix Calcium Resonium powder with lactulose to be taken orallySome units mix dose with a little water and give PR 4 times/day. Not retained for so long, but still effectiveCalcium Resonium is not absorbed
See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
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