Calcium-channel blocker:

Hypertension

Angina prophylaxis

5–10 mg daily

Molecular weight : 567.1 (as besilate)

%Protein binding : >95

%Excreted unchanged in urine :

<10 :

Volume of distribution (L/kg) : 20

half-life – normal/ESRD (hrs) : 35–50/50

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

CAPD : Not dialysed. Dose as in normal renal function

HD : Not dialysed. Dose as in normal renal function

HDF/high flux : Unlikely to be dialysed. Dose as in normal renal function

CAV/VVHD : Not dialysed. Dose as in normal renal function

Potentially hazardous interactions with other drugs

Anaesthetics: enhanced hypotensive effect

Antihypertensives: enhanced hypotensive effect; increased risk of first dose hypotensive effect of post-synaptic alpha- blockers

Antivirals: concentration possibly increased by ritonavir Theophylline: possibly increased theophylline concentration

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Oral

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–

Amlodipine is extensively metabolised to inactive metabolites