ACAMPROSATE CALCIUM
ACAMPROSATE CALCIUM
CLINICAL USE
Maintenance of abstinence in alcohol dependence
DOSE IN NORMAL RENAL FUNCTION
<60 kg: 666 mg 3 times a day>60 kg: 666 mg at breakfast, 333 mg at midday and 333 mg at night PHARMACOKINETICS
Molecular weight :400.5 %Protein binding :0 %Excreted unchanged in urine : Majority Volume of distribution (L/kg) :Approximately 1half-life – normal/ESRD (hrs) :33/85.8 DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
30–50 333 mg 3 times daily10–30 333 mg twice daily <10 : 333 mg once daily DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD :Dialysed. Dose as in GFR <10 mL/min HD :Dialysed. Dose as in GFR <10 mL/min HDF/high flux :Dialysed. Dose as in GFR <10 mL/min CAV/VVHD :Dialysed. Dose as in GFR=10–30 mL/min IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsNone known ADMINISTRATION
Reconstition
– Route
Oral Rate of Administration
–Comments
– OTHER INFORMATION
Recommended treatment period is a year After a single dose of 666 mg in patients with severe renal impairment, the average maximum concentration was 4 times that in healthy individualsBioavailability is reduced if administered with food
See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
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