The following drugs will decrease rolapitant effect

#	enzyme	inducers
0	3A457	barbiturates
1	3A457	brigatinib
2	3A457	carbamazepine
3	3A457	clobazam
4	3A457	dabrafenib
5	3A457	efavirenz
6	3A457	elagolix
7	3A457	enzalutamide
8	3A457	eslicarbazepine
9	3A457	glucocorticoids
10	3A457	letermovir
11	3A457	lorlatinib
12	3A457	modafinil
13	3A457	nevirapine
14	3A457	oxcarbazepine
15	3A457	perampanel
16	3A457	phenobarbital
17	3A457	phenytoin
18	3A457	pioglitazone
19	3A457	rifabutin
20	3A457	rifampin
21	3A457	St. John's Wort
22	3A457	telotristat
23	3A457	troglitazone
24	3A457	vemurafenib

the follwing drugs will Increase rolapitant effect

#	enzyme	Inhibitors	level
0	3A457	amiodarone	under review
1	3A457	aprepitant	Moderate inhibitor
2	3A457	atomoxetine
3	3A457	boceprevir	under review
4	3A457	ceritinib	Strong inhibitor
5	3A457	chloramphenicol	In-Vitro Only
6	3A457	cimetidine
7	3A457	ciprofloxacin	under review
8	3A457	clarithromycin	Strong inhibitor
9	3A457	crizotinib	Moderate inhibitor
10	3A457	delaviridine	under review
11	3A457	diethyl-dithiocarbamate
12	3A457	diltiazem	Moderate inhibitor
13	3A457	entrectinib
14	3A457	erythromycin	Moderate inhibitor
15	3A457	esomeprazole
16	3A457	fluconazole	Moderate inhibitor
17	3A457	fluvoxamine	under review
18	3A457	gestodene	under review
19	3A457	grapefruit juice	Moderate inhibitor
20	3A457	idelalisib	Strong inhibitor
21	3A457	imatinib	under review
22	3A457	indinavir	Strong inhibitor
23	3A457	itraconazole	Strong inhibitor
24	3A457	ivacaftor
25	3A457	ketoconazole	Strong inhibitor
26	3A457	lesinurad
27	3A457	letermovir
28	3A457	mibefradil	Strong inhibitor
29	3A457	mifepristone	under review
30	3A457	nefazodone	Strong inhibitor
31	3A457	nelfinavir	Strong inhibitor
32	3A457	netupitant/palonosetron	Moderate inhibitor
33	3A457	norfloxacin	under review
34	3A457	norfluoxetine	under review
35	3A457	omeprazole	Weak inhibitor
36	3A457	pantoprazole
37	3A457	perampanel
38	3A457	quercetin
39	3A457	regorafenib	under review
40	3A457	ribociclib	Strong inhibitor
41	3A457	ritonavir	Strong inhibitor
42	3A457	rucaparib
43	3A457	saquinavir	Strong inhibitor
44	3A457	simeprevir
45	3A457	starfruit	under review
46	3A457	telaprevir	under review
47	3A457	telithromycin	Strong inhibitor
48	3A457	ticagrelor
49	3A457	tucatinib	Strong inhibitor
50	3A457	verapamil	Moderate inhibitor
51	3A457	voriconazole	Strong inhibitor

The follwing drugs will Increase effect by rolapitant effect

#	enzyme	drug	level
1	2D6	alprenolol	Moderate inhibitor
2	2D6	amitriptyline	Moderate inhibitor
3	2D6	amphetamine	Moderate inhibitor
4	2D6	atomoxetine	Moderate inhibitor
5	2D6	brexpiprazole	Moderate inhibitor
6	2D6	bufuralol	Moderate inhibitor
7	2D6	cariprazine	Moderate inhibitor
8	2D6	carvedilol	Moderate inhibitor
9	2D6	chlorpheniramine	Moderate inhibitor
10	2D6	chlorpromazine	Moderate inhibitor
11	2D6	citalopram	Moderate inhibitor
12	2D6	clomipramine	Moderate inhibitor
13	2D6	clonidine	Moderate inhibitor
14	2D6	codeine	Moderate inhibitor
15	2D6	debrisoquine	Moderate inhibitor
16	2D6	desipramine	Moderate inhibitor
17	2D6	deutetrabenazine	Moderate inhibitor
18	2D6	dexfenfluramine	Moderate inhibitor
19	2D6	dextromethorphan	Moderate inhibitor
20	2D6	donepezil	Moderate inhibitor
21	2D6	doxepin	Moderate inhibitor
22	2D6	eliglustat	Moderate inhibitor
23	2D6	encainide	Moderate inhibitor
24	2D6	escitalopram	Moderate inhibitor
25	2D6	flecainide	Moderate inhibitor
26	2D6	fluoxetine	Moderate inhibitor
27	2D6	fluvoxamine	Moderate inhibitor
28	2D6	ibrutinib	Moderate inhibitor
29	2D6	imipramine	Moderate inhibitor
30	2D6	lidocaine	Moderate inhibitor
31	2D6	metoclopramide	Moderate inhibitor
32	2D6	metoprolol	Moderate inhibitor
33	2D6	mexiletine	Moderate inhibitor
34	2D6	minaprine	Moderate inhibitor
35	2D6	nebivolol	Moderate inhibitor
36	2D6	nortriptyline	Moderate inhibitor
37	2D6	ondansetron	Moderate inhibitor
38	2D6	oxycodone	Moderate inhibitor
39	2D6	paroxetine	Moderate inhibitor
40	2D6	perhexiline	Moderate inhibitor
41	2D6	perphenazine	Moderate inhibitor
42	2D6	phenacetin	Moderate inhibitor
43	2D6	pimavanserin	Moderate inhibitor
44	2D6	ponatinib	Moderate inhibitor
45	2D6	promethazine	Moderate inhibitor
46	2D6	propafenone	Moderate inhibitor
47	2D6	propranolol	Moderate inhibitor
48	2D6	risperidone	Moderate inhibitor
49	2D6	rucaparib	Moderate inhibitor
50	2D6	sparteine	Moderate inhibitor
51	2D6	tamoxifen	Moderate inhibitor
52	2D6	tetrabenzine	Moderate inhibitor
53	2D6	thioridazine	Moderate inhibitor
54	2D6	timolol	Moderate inhibitor
55	2D6	tramadol	Moderate inhibitor
56	2D6	umeclidinium	Moderate inhibitor
57	2D6	valbenazine	Moderate inhibitor
58	2D6	venlafaxine	Moderate inhibitor
59	2D6	vilazodone	Moderate inhibitor
60	2D6	zuclopenthixol	Moderate inhibitor

will decrease rolapitant effect

#

enzyme

inducers

rolapitant will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.