quinidine
The following drugs will decrease quinidine effect
# | enzyme | inducers |
0 | 3A457 | barbiturates |
1 | 3A457 | brigatinib |
2 | 3A457 | carbamazepine |
3 | 3A457 | clobazam |
4 | 3A457 | dabrafenib |
5 | 3A457 | efavirenz |
6 | 3A457 | elagolix |
7 | 3A457 | enzalutamide |
8 | 3A457 | eslicarbazepine |
9 | 3A457 | glucocorticoids |
10 | 3A457 | letermovir |
11 | 3A457 | lorlatinib |
12 | 3A457 | modafinil |
13 | 3A457 | nevirapine |
14 | 3A457 | oxcarbazepine |
15 | 3A457 | perampanel |
16 | 3A457 | phenobarbital |
17 | 3A457 | phenytoin |
18 | 3A457 | pioglitazone |
19 | 3A457 | rifabutin |
20 | 3A457 | rifampin |
21 | 3A457 | St. John's Wort |
22 | 3A457 | telotristat |
23 | 3A457 | troglitazone |
24 | 3A457 | vemurafenib |
the follwing drugs will
Increase quinidine effect
# | enzyme | Inhibitors | level |
0 | 3A457 | amiodarone | under review |
1 | 3A457 | aprepitant | Moderate inhibitor |
2 | 3A457 | atomoxetine | |
3 | 3A457 | boceprevir | under review |
4 | 3A457 | ceritinib | Strong inhibitor |
5 | 3A457 | chloramphenicol | In-Vitro Only |
6 | 3A457 | cimetidine | |
7 | 3A457 | ciprofloxacin | under review |
8 | 3A457 | clarithromycin | Strong inhibitor |
9 | 3A457 | crizotinib | Moderate inhibitor |
10 | 3A457 | delaviridine | under review |
11 | 3A457 | diethyl-dithiocarbamate | |
12 | 3A457 | diltiazem | Moderate inhibitor |
13 | 3A457 | entrectinib | |
14 | 3A457 | erythromycin | Moderate inhibitor |
15 | 3A457 | esomeprazole | |
16 | 3A457 | fluconazole | Moderate inhibitor |
17 | 3A457 | fluvoxamine | under review |
18 | 3A457 | gestodene | under review |
19 | 3A457 | grapefruit juice | Moderate inhibitor |
20 | 3A457 | idelalisib | Strong inhibitor |
21 | 3A457 | imatinib | under review |
22 | 3A457 | indinavir | Strong inhibitor |
23 | 3A457 | itraconazole | Strong inhibitor |
24 | 3A457 | ivacaftor | |
25 | 3A457 | ketoconazole | Strong inhibitor |
26 | 3A457 | lesinurad | |
27 | 3A457 | letermovir | |
28 | 3A457 | mibefradil | Strong inhibitor |
29 | 3A457 | mifepristone | under review |
30 | 3A457 | nefazodone | Strong inhibitor |
31 | 3A457 | nelfinavir | Strong inhibitor |
32 | 3A457 | netupitant/palonosetron | Moderate inhibitor |
33 | 3A457 | norfloxacin | under review |
34 | 3A457 | norfluoxetine | under review |
35 | 3A457 | omeprazole | Weak inhibitor |
36 | 3A457 | pantoprazole | |
37 | 3A457 | perampanel | |
38 | 3A457 | quercetin | |
39 | 3A457 | regorafenib | under review |
40 | 3A457 | ribociclib | Strong inhibitor |
41 | 3A457 | ritonavir | Strong inhibitor |
42 | 3A457 | rucaparib | |
43 | 3A457 | saquinavir | Strong inhibitor |
44 | 3A457 | simeprevir | |
45 | 3A457 | starfruit | under review |
46 | 3A457 | telaprevir | under review |
47 | 3A457 | telithromycin | Strong inhibitor |
48 | 3A457 | ticagrelor | |
49 | 3A457 | tucatinib | Strong inhibitor |
50 | 3A457 | verapamil | Moderate inhibitor |
51 | 3A457 | voriconazole | Strong inhibitor |
The follwing drugs will Increase effect by quinidine effect
# | enzyme | drug | level |
1 | 2D6 | alprenolol | Strong inhibitor |
2 | 2D6 | amitriptyline | Strong inhibitor |
3 | 2D6 | amphetamine | Strong inhibitor |
4 | 2D6 | atomoxetine | Strong inhibitor |
5 | 2D6 | brexpiprazole | Strong inhibitor |
6 | 2D6 | bufuralol | Strong inhibitor |
7 | 2D6 | cariprazine | Strong inhibitor |
8 | 2D6 | carvedilol | Strong inhibitor |
9 | 2D6 | chlorpheniramine | Strong inhibitor |
10 | 2D6 | chlorpromazine | Strong inhibitor |
11 | 2D6 | citalopram | Strong inhibitor |
12 | 2D6 | clomipramine | Strong inhibitor |
13 | 2D6 | clonidine | Strong inhibitor |
14 | 2D6 | codeine | Strong inhibitor |
15 | 2D6 | debrisoquine | Strong inhibitor |
16 | 2D6 | desipramine | Strong inhibitor |
17 | 2D6 | deutetrabenazine | Strong inhibitor |
18 | 2D6 | dexfenfluramine | Strong inhibitor |
19 | 2D6 | dextromethorphan | Strong inhibitor |
20 | 2D6 | donepezil | Strong inhibitor |
21 | 2D6 | doxepin | Strong inhibitor |
22 | 2D6 | eliglustat | Strong inhibitor |
23 | 2D6 | encainide | Strong inhibitor |
24 | 2D6 | escitalopram | Strong inhibitor |
25 | 2D6 | flecainide | Strong inhibitor |
26 | 2D6 | fluoxetine | Strong inhibitor |
27 | 2D6 | fluvoxamine | Strong inhibitor |
28 | 2D6 | ibrutinib | Strong inhibitor |
29 | 2D6 | imipramine | Strong inhibitor |
30 | 2D6 | lidocaine | Strong inhibitor |
31 | 2D6 | metoclopramide | Strong inhibitor |
32 | 2D6 | metoprolol | Strong inhibitor |
33 | 2D6 | mexiletine | Strong inhibitor |
34 | 2D6 | minaprine | Strong inhibitor |
35 | 2D6 | nebivolol | Strong inhibitor |
36 | 2D6 | nortriptyline | Strong inhibitor |
37 | 2D6 | ondansetron | Strong inhibitor |
38 | 2D6 | oxycodone | Strong inhibitor |
39 | 2D6 | paroxetine | Strong inhibitor |
40 | 2D6 | perhexiline | Strong inhibitor |
41 | 2D6 | perphenazine | Strong inhibitor |
42 | 2D6 | phenacetin | Strong inhibitor |
43 | 2D6 | pimavanserin | Strong inhibitor |
44 | 2D6 | ponatinib | Strong inhibitor |
45 | 2D6 | promethazine | Strong inhibitor |
46 | 2D6 | propafenone | Strong inhibitor |
47 | 2D6 | propranolol | Strong inhibitor |
48 | 2D6 | risperidone | Strong inhibitor |
49 | 2D6 | rucaparib | Strong inhibitor |
50 | 2D6 | sparteine | Strong inhibitor |
51 | 2D6 | tamoxifen | Strong inhibitor |
52 | 2D6 | tetrabenzine | Strong inhibitor |
53 | 2D6 | thioridazine | Strong inhibitor |
54 | 2D6 | timolol | Strong inhibitor |
55 | 2D6 | tramadol | Strong inhibitor |
56 | 2D6 | umeclidinium | Strong inhibitor |
57 | 2D6 | valbenazine | Strong inhibitor |
58 | 2D6 | venlafaxine | Strong inhibitor |
59 | 2D6 | vilazodone | Strong inhibitor |
60 | 2D6 | zuclopenthixol | Strong inhibitor |
will
decrease quinidine effect
quinidine will not affect
Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.