The following drugs will decrease promethazine effect

#	enzyme	inducers
0	2D6	ethanol
1	2D6	isoniazid

the follwing drugs will Increase promethazine effect

#	enzyme	Inhibitors	level
0	2D6	abiraterone	Moderate inhibitor
1	2D6	amiodarone	Weak inhibitor
2	2D6	bupropion	Strong inhibitor
3	2D6	celecoxib	Weak inhibitor
4	2D6	chlorpromazine	In-Vitro Only
5	2D6	cimetidine	Weak inhibitor
6	2D6	cinacalcet	Moderate inhibitor
7	2D6	citalopram	Weak inhibitor
8	2D6	clemastine	In-Vitro Only
9	2D6	clobazam
10	2D6	clomipramine
11	2D6	cocaine	In-Vitro Only
12	2D6	diethyl-dithiocarbamate
13	2D6	diphenhydramine
14	2D6	disulfiram
15	2D6	doxepin	Moderate inhibitor
16	2D6	duloxetine	Moderate inhibitor
17	2D6	escitalopram
18	2D6	fluoxetine	Strong inhibitor
19	2D6	halofantrine	Moderate inhibitor
20	2D6	haloperidol	In-Vitro Only
21	2D6	hydroxyzine	In-Vitro Only
22	2D6	levomepromazine
23	2D6	lorcaserin	Moderate inhibitor
24	2D6	methadone	under review
25	2D6	metoclopramide	In-Vitro Only
26	2D6	midodrine
27	2D6	moclobemide	Moderate inhibitor
28	2D6	panobinostat	under review
29	2D6	paroxetine	Strong inhibitor
30	2D6	perphenazine	In-Vitro Only
31	2D6	quercetin
32	2D6	quinidine	Strong inhibitor
33	2D6	ritonavir
34	2D6	rolapitant	Moderate inhibitor
35	2D6	sertraline
36	2D6	terbinafine (oral)	Moderate inhibitor
37	2D6	ticlopidine	In-Vitro Only
38	2D6	tripelennamine	In-Vitro Only
39	2D6	vemurafenib

The follwing drugs will Increase effect by promethazine effect

#	enzyme	drug	level
1	2D6	alprenolol	under review
2	2D6	amitriptyline	under review
3	2D6	amphetamine	under review
4	2D6	atomoxetine	under review
5	2D6	brexpiprazole	under review
6	2D6	bufuralol	under review
7	2D6	cariprazine	under review
8	2D6	carvedilol	under review
9	2D6	chlorpheniramine	under review
10	2D6	chlorpromazine	under review
11	2D6	citalopram	under review
12	2D6	clomipramine	under review
13	2D6	clonidine	under review
14	2D6	codeine	under review
15	2D6	debrisoquine	under review
16	2D6	desipramine	under review
17	2D6	deutetrabenazine	under review
18	2D6	dexfenfluramine	under review
19	2D6	dextromethorphan	under review
20	2D6	donepezil	under review
21	2D6	doxepin	under review
22	2D6	eliglustat	under review
23	2D6	encainide	under review
24	2D6	escitalopram	under review
25	2D6	flecainide	under review
26	2D6	fluoxetine	under review
27	2D6	fluvoxamine	under review
28	2D6	ibrutinib	under review
29	2D6	imipramine	under review
30	2D6	lidocaine	under review
31	2D6	metoclopramide	under review
32	2D6	metoprolol	under review
33	2D6	mexiletine	under review
34	2D6	minaprine	under review
35	2D6	nebivolol	under review
36	2D6	nortriptyline	under review
37	2D6	ondansetron	under review
38	2D6	oxycodone	under review
39	2D6	paroxetine	under review
40	2D6	perhexiline	under review
41	2D6	perphenazine	under review
42	2D6	phenacetin	under review
43	2D6	pimavanserin	under review
44	2D6	ponatinib	under review
45	2D6	propafenone	under review
46	2D6	propranolol	under review
47	2D6	risperidone	under review
48	2D6	rucaparib	under review
49	2D6	sparteine	under review
50	2D6	tamoxifen	under review
51	2D6	tetrabenzine	under review
52	2D6	thioridazine	under review
53	2D6	timolol	under review
54	2D6	tramadol	under review
55	2D6	umeclidinium	under review
56	2D6	valbenazine	under review
57	2D6	venlafaxine	under review
58	2D6	vilazodone	under review
59	2D6	zuclopenthixol	under review

will decrease promethazine effect

#

enzyme

inducers

promethazine will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.