The following drugs will decrease perphenazine effect

#	enzyme	inducers
0	2D6	ethanol
1	2D6	isoniazid

the follwing drugs will Increase perphenazine effect

#	enzyme	Inhibitors	level
0	2D6	abiraterone	Moderate inhibitor
1	2D6	amiodarone	Weak inhibitor
2	2D6	bupropion	Strong inhibitor
3	2D6	celecoxib	Weak inhibitor
4	2D6	chlorpromazine	In-Vitro Only
5	2D6	cimetidine	Weak inhibitor
6	2D6	cinacalcet	Moderate inhibitor
7	2D6	citalopram	Weak inhibitor
8	2D6	clemastine	In-Vitro Only
9	2D6	clobazam
10	2D6	clomipramine
11	2D6	cocaine	In-Vitro Only
12	2D6	diethyl-dithiocarbamate
13	2D6	diphenhydramine
14	2D6	disulfiram
15	2D6	doxepin	Moderate inhibitor
16	2D6	duloxetine	Moderate inhibitor
17	2D6	escitalopram
18	2D6	fluoxetine	Strong inhibitor
19	2D6	halofantrine	Moderate inhibitor
20	2D6	haloperidol	In-Vitro Only
21	2D6	hydroxyzine	In-Vitro Only
22	2D6	levomepromazine
23	2D6	lorcaserin	Moderate inhibitor
24	2D6	methadone	under review
25	2D6	metoclopramide	In-Vitro Only
26	2D6	midodrine
27	2D6	moclobemide	Moderate inhibitor
28	2D6	panobinostat	under review
29	2D6	paroxetine	Strong inhibitor
30	2D6	perphenazine	In-Vitro Only
31	2D6	promethazine	under review
32	2D6	quercetin
33	2D6	quinidine	Strong inhibitor
34	2D6	ritonavir
35	2D6	rolapitant	Moderate inhibitor
36	2D6	sertraline
37	2D6	terbinafine (oral)	Moderate inhibitor
38	2D6	ticlopidine	In-Vitro Only
39	2D6	tripelennamine	In-Vitro Only
40	2D6	vemurafenib

The follwing drugs will Increase effect by perphenazine effect

#	enzyme	drug	level
1	2D6	alprenolol	In-Vitro Only
2	2D6	amitriptyline	In-Vitro Only
3	2D6	amphetamine	In-Vitro Only
4	2D6	atomoxetine	In-Vitro Only
5	2D6	brexpiprazole	In-Vitro Only
6	2D6	bufuralol	In-Vitro Only
7	2D6	cariprazine	In-Vitro Only
8	2D6	carvedilol	In-Vitro Only
9	2D6	chlorpheniramine	In-Vitro Only
10	2D6	chlorpromazine	In-Vitro Only
11	2D6	citalopram	In-Vitro Only
12	2D6	clomipramine	In-Vitro Only
13	2D6	clonidine	In-Vitro Only
14	2D6	codeine	In-Vitro Only
15	2D6	debrisoquine	In-Vitro Only
16	2D6	desipramine	In-Vitro Only
17	2D6	deutetrabenazine	In-Vitro Only
18	2D6	dexfenfluramine	In-Vitro Only
19	2D6	dextromethorphan	In-Vitro Only
20	2D6	donepezil	In-Vitro Only
21	2D6	doxepin	In-Vitro Only
22	2D6	eliglustat	In-Vitro Only
23	2D6	encainide	In-Vitro Only
24	2D6	escitalopram	In-Vitro Only
25	2D6	flecainide	In-Vitro Only
26	2D6	fluoxetine	In-Vitro Only
27	2D6	fluvoxamine	In-Vitro Only
28	2D6	ibrutinib	In-Vitro Only
29	2D6	imipramine	In-Vitro Only
30	2D6	lidocaine	In-Vitro Only
31	2D6	metoclopramide	In-Vitro Only
32	2D6	metoprolol	In-Vitro Only
33	2D6	mexiletine	In-Vitro Only
34	2D6	minaprine	In-Vitro Only
35	2D6	nebivolol	In-Vitro Only
36	2D6	nortriptyline	In-Vitro Only
37	2D6	ondansetron	In-Vitro Only
38	2D6	oxycodone	In-Vitro Only
39	2D6	paroxetine	In-Vitro Only
40	2D6	perhexiline	In-Vitro Only
41	2D6	perphenazine	In-Vitro Only
42	2D6	phenacetin	In-Vitro Only
43	2D6	pimavanserin	In-Vitro Only
44	2D6	ponatinib	In-Vitro Only
45	2D6	promethazine	In-Vitro Only
46	2D6	propafenone	In-Vitro Only
47	2D6	propranolol	In-Vitro Only
48	2D6	risperidone	In-Vitro Only
49	2D6	rucaparib	In-Vitro Only
50	2D6	sparteine	In-Vitro Only
51	2D6	tamoxifen	In-Vitro Only
52	2D6	tetrabenzine	In-Vitro Only
53	2D6	thioridazine	In-Vitro Only
54	2D6	timolol	In-Vitro Only
55	2D6	tramadol	In-Vitro Only
56	2D6	umeclidinium	In-Vitro Only
57	2D6	valbenazine	In-Vitro Only
58	2D6	venlafaxine	In-Vitro Only
59	2D6	vilazodone	In-Vitro Only
60	2D6	zuclopenthixol	In-Vitro Only

will decrease perphenazine effect

#

enzyme

inducers

perphenazine will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.