The following drugs will decrease paroxetine effect

#	enzyme	inducers
0	2D6	ethanol
1	2D6	isoniazid

the follwing drugs will Increase paroxetine effect

#	enzyme	Inhibitors	level
0	2D6	abiraterone	Moderate inhibitor
1	2D6	amiodarone	Weak inhibitor
2	2D6	bupropion	Strong inhibitor
3	2D6	celecoxib	Weak inhibitor
4	2D6	chlorpromazine	In-Vitro Only
5	2D6	cimetidine	Weak inhibitor
6	2D6	cinacalcet	Moderate inhibitor
7	2D6	citalopram	Weak inhibitor
8	2D6	clemastine	In-Vitro Only
9	2D6	clobazam
10	2D6	clomipramine
11	2D6	cocaine	In-Vitro Only
12	2D6	diethyl-dithiocarbamate
13	2D6	diphenhydramine
14	2D6	disulfiram
15	2D6	doxepin	Moderate inhibitor
16	2D6	duloxetine	Moderate inhibitor
17	2D6	escitalopram
18	2D6	fluoxetine	Strong inhibitor
19	2D6	halofantrine	Moderate inhibitor
20	2D6	haloperidol	In-Vitro Only
21	2D6	hydroxyzine	In-Vitro Only
22	2D6	levomepromazine
23	2D6	lorcaserin	Moderate inhibitor
24	2D6	methadone	under review
25	2D6	metoclopramide	In-Vitro Only
26	2D6	midodrine
27	2D6	moclobemide	Moderate inhibitor
28	2D6	panobinostat	under review
29	2D6	paroxetine	Strong inhibitor
30	2D6	perphenazine	In-Vitro Only
31	2D6	promethazine	under review
32	2D6	quercetin
33	2D6	quinidine	Strong inhibitor
34	2D6	ritonavir
35	2D6	rolapitant	Moderate inhibitor
36	2D6	sertraline
37	2D6	terbinafine (oral)	Moderate inhibitor
38	2D6	ticlopidine	In-Vitro Only
39	2D6	tripelennamine	In-Vitro Only
40	2D6	vemurafenib

The follwing drugs will Increase effect by paroxetine effect

#	enzyme	drug	level
1	2D6	alprenolol	Strong inhibitor
2	2D6	amitriptyline	Strong inhibitor
3	2D6	amphetamine	Strong inhibitor
4	2D6	atomoxetine	Strong inhibitor
5	2D6	brexpiprazole	Strong inhibitor
6	2D6	bufuralol	Strong inhibitor
7	2D6	cariprazine	Strong inhibitor
8	2D6	carvedilol	Strong inhibitor
9	2D6	chlorpheniramine	Strong inhibitor
10	2D6	chlorpromazine	Strong inhibitor
11	2D6	citalopram	Strong inhibitor
12	2D6	clomipramine	Strong inhibitor
13	2D6	clonidine	Strong inhibitor
14	2D6	codeine	Strong inhibitor
15	2D6	debrisoquine	Strong inhibitor
16	2D6	desipramine	Strong inhibitor
17	2D6	deutetrabenazine	Strong inhibitor
18	2D6	dexfenfluramine	Strong inhibitor
19	2D6	dextromethorphan	Strong inhibitor
20	2D6	donepezil	Strong inhibitor
21	2D6	doxepin	Strong inhibitor
22	2D6	eliglustat	Strong inhibitor
23	2D6	encainide	Strong inhibitor
24	2D6	escitalopram	Strong inhibitor
25	2D6	flecainide	Strong inhibitor
26	2D6	fluoxetine	Strong inhibitor
27	2D6	fluvoxamine	Strong inhibitor
28	2D6	ibrutinib	Strong inhibitor
29	2D6	imipramine	Strong inhibitor
30	2D6	lidocaine	Strong inhibitor
31	2D6	metoclopramide	Strong inhibitor
32	2D6	metoprolol	Strong inhibitor
33	2D6	mexiletine	Strong inhibitor
34	2D6	minaprine	Strong inhibitor
35	2D6	nebivolol	Strong inhibitor
36	2D6	nortriptyline	Strong inhibitor
37	2D6	ondansetron	Strong inhibitor
38	2D6	oxycodone	Strong inhibitor
39	2D6	paroxetine	Strong inhibitor
40	2D6	perhexiline	Strong inhibitor
41	2D6	perphenazine	Strong inhibitor
42	2D6	phenacetin	Strong inhibitor
43	2D6	pimavanserin	Strong inhibitor
44	2D6	ponatinib	Strong inhibitor
45	2D6	promethazine	Strong inhibitor
46	2D6	propafenone	Strong inhibitor
47	2D6	propranolol	Strong inhibitor
48	2D6	risperidone	Strong inhibitor
49	2D6	rucaparib	Strong inhibitor
50	2D6	sparteine	Strong inhibitor
51	2D6	tamoxifen	Strong inhibitor
52	2D6	tetrabenzine	Strong inhibitor
53	2D6	thioridazine	Strong inhibitor
54	2D6	timolol	Strong inhibitor
55	2D6	tramadol	Strong inhibitor
56	2D6	umeclidinium	Strong inhibitor
57	2D6	valbenazine	Strong inhibitor
58	2D6	venlafaxine	Strong inhibitor
59	2D6	vilazodone	Strong inhibitor
60	2D6	zuclopenthixol	Strong inhibitor

will decrease paroxetine effect

#

enzyme

inducers

paroxetine will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.