The following drugs will decrease methadone effect

#	enzyme	inducers
0	3A457	barbiturates
1	3A457	brigatinib
2	3A457	carbamazepine
3	3A457	clobazam
4	3A457	dabrafenib
5	3A457	efavirenz
6	3A457	elagolix
7	3A457	enzalutamide
8	3A457	eslicarbazepine
9	2B6	artemisinin
10	3A457	glucocorticoids
11	3A457	letermovir
12	3A457	lorlatinib
13	3A457	modafinil
14	3A457	nevirapine
15	3A457	oxcarbazepine
16	3A457	perampanel
17	3A457	phenobarbital
18	3A457	phenytoin
19	3A457	pioglitazone
20	3A457	rifabutin
21	3A457	rifampin
22	3A457	St. John's Wort
23	3A457	telotristat
24	3A457	troglitazone
25	3A457	vemurafenib
26	2B6	carbamazepine
27	2B6	dabrafenib
28	2B6	efavirenz
29	2B6	letermovir
30	2B6	nevirapine
31	2B6	perampanel
32	2B6	phenobarbital
33	2B6	phenytoin
34	2B6	rifampin
35	2B6	roflumilast

the follwing drugs will Increase methadone effect

#	enzyme	Inhibitors	level
0	3A457	amiodarone	under review
1	3A457	aprepitant	Moderate inhibitor
2	3A457	atomoxetine
3	3A457	boceprevir	under review
4	3A457	ceritinib	Strong inhibitor
5	3A457	chloramphenicol	In-Vitro Only
6	3A457	cimetidine
7	3A457	ciprofloxacin	under review
8	3A457	clarithromycin	Strong inhibitor
9	2B6	clopidogrel	Weak inhibitor
10	3A457	crizotinib	Moderate inhibitor
11	3A457	delaviridine	under review
12	3A457	diethyl-dithiocarbamate
13	3A457	diltiazem	Moderate inhibitor
14	3A457	entrectinib
15	3A457	erythromycin	Moderate inhibitor
16	3A457	esomeprazole
17	3A457	fluconazole	Moderate inhibitor
18	3A457	fluvoxamine	under review
19	3A457	gestodene	under review
20	3A457	grapefruit juice	Moderate inhibitor
21	3A457	idelalisib	Strong inhibitor
22	3A457	imatinib	under review
23	3A457	indinavir	Strong inhibitor
24	3A457	itraconazole	Strong inhibitor
25	3A457	ivacaftor
26	3A457	ketoconazole	Strong inhibitor
27	3A457	lesinurad
28	3A457	letermovir
29	3A457	mibefradil	Strong inhibitor
30	3A457	mifepristone	under review
31	3A457	nefazodone	Strong inhibitor
32	3A457	nelfinavir	Strong inhibitor
33	3A457	netupitant/palonosetron	Moderate inhibitor
34	3A457	norfloxacin	under review
35	3A457	norfluoxetine	under review
36	3A457	omeprazole	Weak inhibitor
37	3A457	pantoprazole
38	3A457	perampanel
39	3A457	quercetin
40	3A457	regorafenib	under review
41	3A457	ribociclib	Strong inhibitor
42	3A457	ritonavir	Strong inhibitor
43	3A457	rucaparib
44	3A457	saquinavir	Strong inhibitor
45	3A457	simeprevir
46	3A457	starfruit	under review
47	3A457	telaprevir	under review
48	3A457	telithromycin	Strong inhibitor
49	2B6	thiotepa	Weak inhibitor
50	3A457	ticagrelor
51	2B6	ticlopidine	Strong inhibitor
52	3A457	tucatinib	Strong inhibitor
53	3A457	verapamil	Moderate inhibitor
54	2B6	voriconazole	Moderate inhibitor
55	3A457	voriconazole	Strong inhibitor

The follwing drugs will Increase effect by methadone effect

#	enzyme	drug	level
1	2D6	alprenolol	under review
2	2D6	amitriptyline	under review
3	2D6	amphetamine	under review
4	2D6	atomoxetine	under review
5	2D6	brexpiprazole	under review
6	2D6	bufuralol	under review
7	2D6	cariprazine	under review
8	2D6	carvedilol	under review
9	2D6	chlorpheniramine	under review
10	2D6	chlorpromazine	under review
11	2D6	citalopram	under review
12	2D6	clomipramine	under review
13	2D6	clonidine	under review
14	2D6	codeine	under review
15	2D6	debrisoquine	under review
16	2D6	desipramine	under review
17	2D6	deutetrabenazine	under review
18	2D6	dexfenfluramine	under review
19	2D6	dextromethorphan	under review
20	2D6	donepezil	under review
21	2D6	doxepin	under review
22	2D6	eliglustat	under review
23	2D6	encainide	under review
24	2D6	escitalopram	under review
25	2D6	flecainide	under review
26	2D6	fluoxetine	under review
27	2D6	fluvoxamine	under review
28	2D6	ibrutinib	under review
29	2D6	imipramine	under review
30	2D6	lidocaine	under review
31	2D6	metoclopramide	under review
32	2D6	metoprolol	under review
33	2D6	mexiletine	under review
34	2D6	minaprine	under review
35	2D6	nebivolol	under review
36	2D6	nortriptyline	under review
37	2D6	ondansetron	under review
38	2D6	oxycodone	under review
39	2D6	paroxetine	under review
40	2D6	perhexiline	under review
41	2D6	perphenazine	under review
42	2D6	phenacetin	under review
43	2D6	pimavanserin	under review
44	2D6	ponatinib	under review
45	2D6	promethazine	under review
46	2D6	propafenone	under review
47	2D6	propranolol	under review
48	2D6	risperidone	under review
49	2D6	rucaparib	under review
50	2D6	sparteine	under review
51	2D6	tamoxifen	under review
52	2D6	tetrabenzine	under review
53	2D6	thioridazine	under review
54	2D6	timolol	under review
55	2D6	tramadol	under review
56	2D6	umeclidinium	under review
57	2D6	valbenazine	under review
58	2D6	venlafaxine	under review
59	2D6	vilazodone	under review
60	2D6	zuclopenthixol	under review

will decrease methadone effect

#

enzyme

inducers

methadone will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.