haloperidol
The following drugs will decrease haloperidol effect
# | enzyme | inducers |
0 | 1A2 | beta-naphthoflavone |
1 | 3A457 | barbiturates |
2 | 3A457 | brigatinib |
3 | 3A457 | carbamazepine |
4 | 3A457 | clobazam |
5 | 3A457 | dabrafenib |
6 | 3A457 | efavirenz |
7 | 1A2 | broccoli |
8 | 3A457 | elagolix |
9 | 1A2 | brussel sprouts |
10 | 3A457 | enzalutamide |
11 | 1A2 | carbamazepine |
12 | 3A457 | eslicarbazepine |
13 | 3A457 | glucocorticoids |
14 | 3A457 | letermovir |
15 | 3A457 | lorlatinib |
16 | 3A457 | modafinil |
17 | 1A2 | char-grilled meat |
18 | 3A457 | nevirapine |
19 | 3A457 | oxcarbazepine |
20 | 3A457 | perampanel |
21 | 3A457 | phenobarbital |
22 | 1A2 | insulin |
23 | 3A457 | phenytoin |
24 | 1A2 | methylcholanthrene |
25 | 3A457 | pioglitazone |
26 | 3A457 | rifabutin |
27 | 3A457 | rifampin |
28 | 3A457 | St. John's Wort |
29 | 3A457 | telotristat |
30 | 3A457 | troglitazone |
31 | 3A457 | vemurafenib |
32 | 1A2 | modafinil |
33 | 1A2 | nafcillin |
34 | 1A2 | omeprazole |
35 | 1A2 | rifampin |
36 | 1A2 | rucaparib |
37 | 1A2 | teriflunomide |
38 | 1A2 | tobacco |
the follwing drugs will
Increase haloperidol effect
# | enzyme | Inhibitors | level |
0 | 1A2 | amiodarone | |
1 | 3A457 | amiodarone | under review |
2 | 3A457 | aprepitant | Moderate inhibitor |
3 | 3A457 | atomoxetine | |
4 | 3A457 | boceprevir | under review |
5 | 3A457 | ceritinib | Strong inhibitor |
6 | 3A457 | chloramphenicol | In-Vitro Only |
7 | 1A2 | cimetidine | Weak inhibitor |
8 | 3A457 | cimetidine | |
9 | 1A2 | ciprofloxacin | |
10 | 3A457 | ciprofloxacin | under review |
11 | 1A2 | citalopram | Weak inhibitor |
12 | 3A457 | clarithromycin | Strong inhibitor |
13 | 3A457 | crizotinib | Moderate inhibitor |
14 | 3A457 | delaviridine | under review |
15 | 3A457 | diethyl-dithiocarbamate | |
16 | 3A457 | diltiazem | Moderate inhibitor |
17 | 1A2 | efavirenz | Weak inhibitor |
18 | 3A457 | entrectinib | |
19 | 3A457 | erythromycin | Moderate inhibitor |
20 | 3A457 | esomeprazole | |
21 | 3A457 | fluconazole | Moderate inhibitor |
22 | 1A2 | fluvoxamine | Strong inhibitor |
23 | 3A457 | fluvoxamine | under review |
24 | 1A2 | furafylline | In-Vitro Only |
25 | 3A457 | gestodene | under review |
26 | 3A457 | grapefruit juice | Moderate inhibitor |
27 | 3A457 | idelalisib | Strong inhibitor |
28 | 3A457 | imatinib | under review |
29 | 3A457 | indinavir | Strong inhibitor |
30 | 3A457 | itraconazole | Strong inhibitor |
31 | 3A457 | ivacaftor | |
32 | 3A457 | ketoconazole | Strong inhibitor |
33 | 3A457 | lesinurad | |
34 | 3A457 | letermovir | |
35 | 1A2 | methoxsalen | In-Vitro Only |
36 | 3A457 | mibefradil | Strong inhibitor |
37 | 3A457 | mifepristone | under review |
38 | 3A457 | nefazodone | Strong inhibitor |
39 | 3A457 | nelfinavir | Strong inhibitor |
40 | 3A457 | netupitant/palonosetron | Moderate inhibitor |
41 | 3A457 | norfloxacin | under review |
42 | 3A457 | norfluoxetine | under review |
43 | 3A457 | omeprazole | Weak inhibitor |
44 | 3A457 | pantoprazole | |
45 | 3A457 | perampanel | |
46 | 1A2 | quercetin | Weak inhibitor |
47 | 3A457 | quercetin | |
48 | 3A457 | regorafenib | under review |
49 | 1A2 | ribociclib | Weak inhibitor |
50 | 3A457 | ribociclib | Strong inhibitor |
51 | 3A457 | ritonavir | Strong inhibitor |
52 | 3A457 | rucaparib | |
53 | 3A457 | saquinavir | Strong inhibitor |
54 | 1A2 | simeprevir | Weak inhibitor |
55 | 3A457 | simeprevir | |
56 | 3A457 | starfruit | under review |
57 | 3A457 | telaprevir | under review |
58 | 3A457 | telithromycin | Strong inhibitor |
59 | 3A457 | ticagrelor | |
60 | 3A457 | tucatinib | Strong inhibitor |
61 | 1A2 | vemurafenib | Moderate inhibitor |
62 | 3A457 | verapamil | Moderate inhibitor |
63 | 3A457 | voriconazole | Strong inhibitor |
The follwing drugs will Increase effect by haloperidol effect
# | enzyme | drug | level |
1 | 2D6 | alprenolol | In-Vitro Only |
2 | 2D6 | amitriptyline | In-Vitro Only |
3 | 2D6 | amphetamine | In-Vitro Only |
4 | 2D6 | atomoxetine | In-Vitro Only |
5 | 2D6 | brexpiprazole | In-Vitro Only |
6 | 2D6 | bufuralol | In-Vitro Only |
7 | 2D6 | cariprazine | In-Vitro Only |
8 | 2D6 | carvedilol | In-Vitro Only |
9 | 2D6 | chlorpheniramine | In-Vitro Only |
10 | 2D6 | chlorpromazine | In-Vitro Only |
11 | 2D6 | citalopram | In-Vitro Only |
12 | 2D6 | clomipramine | In-Vitro Only |
13 | 2D6 | clonidine | In-Vitro Only |
14 | 2D6 | codeine | In-Vitro Only |
15 | 2D6 | debrisoquine | In-Vitro Only |
16 | 2D6 | desipramine | In-Vitro Only |
17 | 2D6 | deutetrabenazine | In-Vitro Only |
18 | 2D6 | dexfenfluramine | In-Vitro Only |
19 | 2D6 | dextromethorphan | In-Vitro Only |
20 | 2D6 | donepezil | In-Vitro Only |
21 | 2D6 | doxepin | In-Vitro Only |
22 | 2D6 | eliglustat | In-Vitro Only |
23 | 2D6 | encainide | In-Vitro Only |
24 | 2D6 | escitalopram | In-Vitro Only |
25 | 2D6 | flecainide | In-Vitro Only |
26 | 2D6 | fluoxetine | In-Vitro Only |
27 | 2D6 | fluvoxamine | In-Vitro Only |
28 | 2D6 | ibrutinib | In-Vitro Only |
29 | 2D6 | imipramine | In-Vitro Only |
30 | 2D6 | lidocaine | In-Vitro Only |
31 | 2D6 | metoclopramide | In-Vitro Only |
32 | 2D6 | metoprolol | In-Vitro Only |
33 | 2D6 | mexiletine | In-Vitro Only |
34 | 2D6 | minaprine | In-Vitro Only |
35 | 2D6 | nebivolol | In-Vitro Only |
36 | 2D6 | nortriptyline | In-Vitro Only |
37 | 2D6 | ondansetron | In-Vitro Only |
38 | 2D6 | oxycodone | In-Vitro Only |
39 | 2D6 | paroxetine | In-Vitro Only |
40 | 2D6 | perhexiline | In-Vitro Only |
41 | 2D6 | perphenazine | In-Vitro Only |
42 | 2D6 | phenacetin | In-Vitro Only |
43 | 2D6 | pimavanserin | In-Vitro Only |
44 | 2D6 | ponatinib | In-Vitro Only |
45 | 2D6 | promethazine | In-Vitro Only |
46 | 2D6 | propafenone | In-Vitro Only |
47 | 2D6 | propranolol | In-Vitro Only |
48 | 2D6 | risperidone | In-Vitro Only |
49 | 2D6 | rucaparib | In-Vitro Only |
50 | 2D6 | sparteine | In-Vitro Only |
51 | 2D6 | tamoxifen | In-Vitro Only |
52 | 2D6 | tetrabenzine | In-Vitro Only |
53 | 2D6 | thioridazine | In-Vitro Only |
54 | 2D6 | timolol | In-Vitro Only |
55 | 2D6 | tramadol | In-Vitro Only |
56 | 2D6 | umeclidinium | In-Vitro Only |
57 | 2D6 | valbenazine | In-Vitro Only |
58 | 2D6 | venlafaxine | In-Vitro Only |
59 | 2D6 | vilazodone | In-Vitro Only |
60 | 2D6 | zuclopenthixol | In-Vitro Only |
will
decrease haloperidol effect
haloperidol will not affect
Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.