halofantrine
The following drugs will decrease halofantrine effect
the follwing drugs will
Increase halofantrine effect
The follwing drugs will Increase effect by halofantrine effect
# | enzyme | drug | level |
1 | 2D6 | alprenolol | Moderate inhibitor |
2 | 2D6 | amitriptyline | Moderate inhibitor |
3 | 2D6 | amphetamine | Moderate inhibitor |
4 | 2D6 | atomoxetine | Moderate inhibitor |
5 | 2D6 | brexpiprazole | Moderate inhibitor |
6 | 2D6 | bufuralol | Moderate inhibitor |
7 | 2D6 | cariprazine | Moderate inhibitor |
8 | 2D6 | carvedilol | Moderate inhibitor |
9 | 2D6 | chlorpheniramine | Moderate inhibitor |
10 | 2D6 | chlorpromazine | Moderate inhibitor |
11 | 2D6 | citalopram | Moderate inhibitor |
12 | 2D6 | clomipramine | Moderate inhibitor |
13 | 2D6 | clonidine | Moderate inhibitor |
14 | 2D6 | codeine | Moderate inhibitor |
15 | 2D6 | debrisoquine | Moderate inhibitor |
16 | 2D6 | desipramine | Moderate inhibitor |
17 | 2D6 | deutetrabenazine | Moderate inhibitor |
18 | 2D6 | dexfenfluramine | Moderate inhibitor |
19 | 2D6 | dextromethorphan | Moderate inhibitor |
20 | 2D6 | donepezil | Moderate inhibitor |
21 | 2D6 | doxepin | Moderate inhibitor |
22 | 2D6 | eliglustat | Moderate inhibitor |
23 | 2D6 | encainide | Moderate inhibitor |
24 | 2D6 | escitalopram | Moderate inhibitor |
25 | 2D6 | flecainide | Moderate inhibitor |
26 | 2D6 | fluoxetine | Moderate inhibitor |
27 | 2D6 | fluvoxamine | Moderate inhibitor |
28 | 2D6 | ibrutinib | Moderate inhibitor |
29 | 2D6 | imipramine | Moderate inhibitor |
30 | 2D6 | lidocaine | Moderate inhibitor |
31 | 2D6 | metoclopramide | Moderate inhibitor |
32 | 2D6 | metoprolol | Moderate inhibitor |
33 | 2D6 | mexiletine | Moderate inhibitor |
34 | 2D6 | minaprine | Moderate inhibitor |
35 | 2D6 | nebivolol | Moderate inhibitor |
36 | 2D6 | nortriptyline | Moderate inhibitor |
37 | 2D6 | ondansetron | Moderate inhibitor |
38 | 2D6 | oxycodone | Moderate inhibitor |
39 | 2D6 | paroxetine | Moderate inhibitor |
40 | 2D6 | perhexiline | Moderate inhibitor |
41 | 2D6 | perphenazine | Moderate inhibitor |
42 | 2D6 | phenacetin | Moderate inhibitor |
43 | 2D6 | pimavanserin | Moderate inhibitor |
44 | 2D6 | ponatinib | Moderate inhibitor |
45 | 2D6 | promethazine | Moderate inhibitor |
46 | 2D6 | propafenone | Moderate inhibitor |
47 | 2D6 | propranolol | Moderate inhibitor |
48 | 2D6 | risperidone | Moderate inhibitor |
49 | 2D6 | rucaparib | Moderate inhibitor |
50 | 2D6 | sparteine | Moderate inhibitor |
51 | 2D6 | tamoxifen | Moderate inhibitor |
52 | 2D6 | tetrabenzine | Moderate inhibitor |
53 | 2D6 | thioridazine | Moderate inhibitor |
54 | 2D6 | timolol | Moderate inhibitor |
55 | 2D6 | tramadol | Moderate inhibitor |
56 | 2D6 | umeclidinium | Moderate inhibitor |
57 | 2D6 | valbenazine | Moderate inhibitor |
58 | 2D6 | venlafaxine | Moderate inhibitor |
59 | 2D6 | vilazodone | Moderate inhibitor |
60 | 2D6 | zuclopenthixol | Moderate inhibitor |
will
decrease halofantrine effect
halofantrine will not affect
Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.