fluvastatin
The following drugs will decrease fluvastatin effect
# | enzyme | inducers |
0 | 2C9 | carbamazepine |
1 | 2C9 | dabrafenib |
2 | 2C9 | enzalutamide |
3 | 2C9 | letermovir |
4 | 2C9 | nevirapine |
5 | 2C9 | phenobarbital |
6 | 2C9 | rifampin |
7 | 2C9 | secobarbital |
the follwing drugs will
Increase fluvastatin effect
# | enzyme | Inhibitors | level |
0 | 2C9 | amiodarone | Moderate inhibitor |
1 | 2C9 | capecitabine | Weak inhibitor |
2 | 2C9 | ceritinib | Weak inhibitor |
3 | 2C9 | efavirenz | Weak inhibitor |
4 | 2C9 | fenofibrate | In-Vitro Only |
5 | 2C9 | fluconazole | Moderate inhibitor |
6 | 2C9 | fluvoxamine | In-Vitro Only |
7 | 2C9 | isoniazid | Weak inhibitor |
8 | 2C9 | metronidazole | Moderate inhibitor |
9 | 2C9 | phenylbutazone | Moderate inhibitor |
10 | 2C9 | quercetin | Weak inhibitor |
11 | 2C9 | sulfamethoxazole | Weak inhibitor |
12 | 2C9 | sulfaphenazole | Strong inhibitor |
13 | 2C9 | voriconazole | Weak inhibitor |
14 | 2C9 | zafirlukast | Weak inhibitor |
The follwing drugs will Increase effect by fluvastatin effect
# | enzyme | drug | level |
1 | 2C9 | amitriptyline | In-Vitro Only |
2 | 2C9 | azilsartan | In-Vitro Only |
3 | 2C9 | capecitabine | In-Vitro Only |
4 | 2C9 | celecoxib | In-Vitro Only |
5 | 2C9 | clopidogrel | In-Vitro Only |
6 | 2C9 | diclofenac | In-Vitro Only |
7 | 2C9 | doxepin | In-Vitro Only |
8 | 2C9 | fluoxetine | In-Vitro Only |
9 | 2C9 | glibenclamide | In-Vitro Only |
10 | 2C9 | glimepiride | In-Vitro Only |
11 | 2C9 | glipizide | In-Vitro Only |
12 | 2C9 | glyburide | In-Vitro Only |
13 | 2C9 | ibuprofen | In-Vitro Only |
14 | 2C9 | irbesartan | In-Vitro Only |
15 | 2C9 | lesinurad | In-Vitro Only |
16 | 2C9 | lornoxicam | In-Vitro Only |
17 | 2C9 | losartan | In-Vitro Only |
18 | 2C9 | meloxicam | In-Vitro Only |
19 | 2C9 | nateglinide | In-Vitro Only |
20 | 2C9 | olodaterol | In-Vitro Only |
21 | 2C9 | ospemifene | In-Vitro Only |
22 | 2C9 | phenytoin | In-Vitro Only |
23 | 2C9 | piroxicam | In-Vitro Only |
24 | 2C9 | rosiglitazone | In-Vitro Only |
25 | 2C9 | s-warfarin | In-Vitro Only |
26 | 2C9 | suprofen | In-Vitro Only |
27 | 2C9 | tamoxifen | In-Vitro Only |
28 | 2C9 | tolbutamide | In-Vitro Only |
29 | 2C9 | torsemide | In-Vitro Only |
30 | 2C9 | valproic acid | In-Vitro Only |
31 | 2C9 | venlafaxine | In-Vitro Only |
32 | 2C9 | voriconazole | In-Vitro Only |
33 | 2C9 | zafirlukast | In-Vitro Only |
will
decrease fluvastatin effect
fluvastatin will not affect
Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.