ethanol
The following drugs will decrease ethanol effect
# | enzyme | inducers |
0 | 2E1 | ethanol |
1 | 2E1 | isoniazid |
the follwing drugs will
Increase ethanol effect
# | enzyme | Inhibitors | level |
0 | 2E1 | diethyl-dithiocarbamate | under review |
1 | 2E1 | disulfiram | Strong inhibitor |
2 | 2E1 | quercetin | |
The following drugs will decreased effect by ethanol effect
# | enzyme | drug |
1 | 2E1 | acetaminophen |
2 | 2E1 | aniline |
3 | 2E1 | chlorzoxazone |
4 | 2E1 | enflurane |
5 | 2E1 | ethanol |
6 | 2E1 | halothane |
7 | 2E1 | isoflurane |
8 | 2E1 | methoxyflurane |
9 | 2D6 | metoclopramide |
10 | 2D6 | mexiletine |
11 | 2D6 | minaprine |
12 | 2E1 | n,n-dimethylformamide |
13 | 2D6 | netupitant/palonosetron |
14 | 2D6 | nortriptyline |
15 | 2D6 | ondansetron |
16 | 2D6 | oxycodone |
17 | 2D6 | paroxetine |
18 | 2D6 | perhexiline |
19 | 2D6 | perphenazine |
20 | 2D6 | phenacetin |
21 | 2D6 | phenformin |
22 | 2D6 | pimavanserin |
23 | 2D6 | pomalidomide |
24 | 2D6 | ponatinib |
25 | 2D6 | promethazine |
26 | 2D6 | propafenone |
27 | 2D6 | propranolol |
28 | 2D6 | rucaparib |
29 | 2E1 | sevoflurane |
30 | 2D6 | sparteine |
31 | 2D6 | tamoxifen |
32 | 2D6 | tetrabenzine |
33 | 2E1 | theophylline |
34 | 2D6 | thioridazine |
35 | 2D6 | timolol |
36 | 2D6 | tramadol |
37 | 2D6 | umeclidinium |
38 | 2D6 | valbenazine |
39 | 2D6 | venlafaxine |
40 | 2D6 | vilazodone |
41 | 2D6 | zuclopenthixol |
will
decrease ethanol effect
ethanol will not affect
Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.