ethanol
The following drugs will decrease ethanol effect
| # | enzyme | inducers |
| 0 | 2E1 | ethanol |
| 1 | 2E1 | isoniazid |
the follwing drugs will
Increase ethanol effect
| # | enzyme | Inhibitors | level |
| 0 | 2E1 | diethyl-dithiocarbamate | under review |
| 1 | 2E1 | disulfiram | Strong inhibitor |
| 2 | 2E1 | quercetin | |
The following drugs will decreased effect by ethanol effect
| # | enzyme | drug |
| 1 | 2E1 | acetaminophen |
| 2 | 2E1 | aniline |
| 3 | 2E1 | chlorzoxazone |
| 4 | 2E1 | enflurane |
| 5 | 2E1 | ethanol |
| 6 | 2E1 | halothane |
| 7 | 2E1 | isoflurane |
| 8 | 2E1 | methoxyflurane |
| 9 | 2D6 | metoclopramide |
| 10 | 2D6 | mexiletine |
| 11 | 2D6 | minaprine |
| 12 | 2E1 | n,n-dimethylformamide |
| 13 | 2D6 | netupitant/palonosetron |
| 14 | 2D6 | nortriptyline |
| 15 | 2D6 | ondansetron |
| 16 | 2D6 | oxycodone |
| 17 | 2D6 | paroxetine |
| 18 | 2D6 | perhexiline |
| 19 | 2D6 | perphenazine |
| 20 | 2D6 | phenacetin |
| 21 | 2D6 | phenformin |
| 22 | 2D6 | pimavanserin |
| 23 | 2D6 | pomalidomide |
| 24 | 2D6 | ponatinib |
| 25 | 2D6 | promethazine |
| 26 | 2D6 | propafenone |
| 27 | 2D6 | propranolol |
| 28 | 2D6 | rucaparib |
| 29 | 2E1 | sevoflurane |
| 30 | 2D6 | sparteine |
| 31 | 2D6 | tamoxifen |
| 32 | 2D6 | tetrabenzine |
| 33 | 2E1 | theophylline |
| 34 | 2D6 | thioridazine |
| 35 | 2D6 | timolol |
| 36 | 2D6 | tramadol |
| 37 | 2D6 | umeclidinium |
| 38 | 2D6 | valbenazine |
| 39 | 2D6 | venlafaxine |
| 40 | 2D6 | vilazodone |
| 41 | 2D6 | zuclopenthixol |
will
decrease ethanol effect
ethanol will not affect
Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.