The following drugs will decrease doxepin effect

#	enzyme	inducers
0	1A2	beta-naphthoflavone
1	2C9	carbamazepine
2	3A457	barbiturates
3	3A457	brigatinib
4	2C19	carbamazepine
5	3A457	carbamazepine
6	3A457	clobazam
7	2C9	dabrafenib
8	2C9	enzalutamide
9	3A457	dabrafenib
10	2C19	efavirenz
11	3A457	efavirenz
12	1A2	broccoli
13	2C19	enzalutamide
14	3A457	elagolix
15	1A2	brussel sprouts
16	3A457	enzalutamide
17	1A2	carbamazepine
18	2C19	letermovir
19	3A457	eslicarbazepine
20	3A457	glucocorticoids
21	3A457	letermovir
22	3A457	lorlatinib
23	3A457	modafinil
24	1A2	char-grilled meat
25	2C9	letermovir
26	3A457	nevirapine
27	3A457	oxcarbazepine
28	2C19	norethindrone
29	3A457	perampanel
30	2C19	prednisone
31	2C9	nevirapine
32	2C9	phenobarbital
33	2C19	rifampicin
34	3A457	phenobarbital
35	2C19	ritonavir
36	2C9	rifampin
37	1A2	insulin
38	2C9	secobarbital
39	3A457	phenytoin
40	1A2	methylcholanthrene
41	3A457	pioglitazone
42	3A457	rifabutin
43	3A457	rifampin
44	3A457	St. John's Wort
45	3A457	telotristat
46	3A457	troglitazone
47	3A457	vemurafenib
48	1A2	modafinil
49	1A2	nafcillin
50	1A2	omeprazole
51	1A2	rifampin
52	1A2	rucaparib
53	1A2	teriflunomide
54	1A2	tobacco

the follwing drugs will Increase doxepin effect

#	enzyme	Inhibitors	level
0	2D6	abiraterone	Moderate inhibitor
1	1A2	amiodarone
2	2C9	amiodarone	Moderate inhibitor
3	2D6	amiodarone	Weak inhibitor
4	3A457	amiodarone	under review
5	3A457	aprepitant	Moderate inhibitor
6	2C19	armodafinil	Weak inhibitor
7	3A457	atomoxetine
8	3A457	boceprevir	under review
9	2D6	bupropion	Strong inhibitor
10	2C9	capecitabine	Weak inhibitor
11	2D6	celecoxib	Weak inhibitor
12	2C9	ceritinib	Weak inhibitor
13	3A457	ceritinib	Strong inhibitor
14	2C19	chloramphenicol	In-Vitro Only
15	3A457	chloramphenicol	In-Vitro Only
16	2D6	chlorpromazine	In-Vitro Only
17	1A2	cimetidine	Weak inhibitor
18	2C19	cimetidine	Weak inhibitor
19	2D6	cimetidine	Weak inhibitor
20	3A457	cimetidine
21	2D6	cinacalcet	Moderate inhibitor
22	1A2	ciprofloxacin
23	3A457	ciprofloxacin	under review
24	1A2	citalopram	Weak inhibitor
25	2C19	citalopram	Weak inhibitor
26	2D6	citalopram	Weak inhibitor
27	3A457	clarithromycin	Strong inhibitor
28	2D6	clemastine	In-Vitro Only
29	2D6	clobazam
30	2D6	clomipramine
31	2D6	cocaine	In-Vitro Only
32	3A457	crizotinib	Moderate inhibitor
33	3A457	delaviridine	under review
34	3A457	diethyl-dithiocarbamate
35	3A457	diltiazem	Moderate inhibitor
36	2D6	diphenhydramine
37	2D6	doxepin	Moderate inhibitor
38	2D6	duloxetine	Moderate inhibitor
39	1A2	efavirenz	Weak inhibitor
40	2C9	efavirenz	Weak inhibitor
41	3A457	entrectinib
42	3A457	erythromycin	Moderate inhibitor
43	2D6	escitalopram
44	2C19	esomeprazole	Weak inhibitor
45	3A457	esomeprazole
46	2C19	felbamate	Weak inhibitor
47	2C9	fenofibrate	In-Vitro Only
48	2C9	fluconazole	Moderate inhibitor
49	2C19	fluconazole	Moderate inhibitor
50	3A457	fluconazole	Moderate inhibitor
51	2C19	fluoxetine	Moderate inhibitor
52	2D6	fluoxetine	Strong inhibitor
53	2C9	fluvastatin	In-Vitro Only
54	1A2	fluvoxamine	Strong inhibitor
55	2C9	fluvoxamine	In-Vitro Only
56	2C19	fluvoxamine	Strong inhibitor
57	3A457	fluvoxamine	under review
58	1A2	furafylline	In-Vitro Only
59	3A457	gestodene	under review
60	3A457	grapefruit juice	Moderate inhibitor
61	2D6	halofantrine	Moderate inhibitor
62	2D6	haloperidol	In-Vitro Only
63	2D6	hydroxyzine	In-Vitro Only
64	3A457	idelalisib	Strong inhibitor
65	3A457	imatinib	under review
66	3A457	indinavir	Strong inhibitor
67	2C9	isoniazid	Weak inhibitor
68	2C19	isoniazid	Weak inhibitor
69	3A457	itraconazole	Strong inhibitor
70	3A457	ivacaftor
71	2C19	ketoconazole	Moderate inhibitor
72	3A457	ketoconazole	Strong inhibitor
73	3A457	lesinurad
74	3A457	letermovir
75	2D6	levomepromazine
76	2D6	lorcaserin	Moderate inhibitor
77	2C19	luliconazole	Weak inhibitor
78	2D6	methadone	under review
79	1A2	methoxsalen	In-Vitro Only
80	2D6	metoclopramide	In-Vitro Only
81	2C9	metronidazole	Moderate inhibitor
82	3A457	mibefradil	Strong inhibitor
83	2D6	midodrine
84	3A457	mifepristone	under review
85	2D6	moclobemide	Moderate inhibitor
86	2C19	modafinil	Weak inhibitor
87	3A457	nefazodone	Strong inhibitor
88	3A457	nelfinavir	Strong inhibitor
89	3A457	netupitant/palonosetron	Moderate inhibitor
90	3A457	norfloxacin	under review
91	3A457	norfluoxetine	under review
92	2C19	omeprazole	Weak inhibitor
93	3A457	omeprazole	Weak inhibitor
94	2C19	oral contraceptives	Weak inhibitor
95	2C19	oritavancin	In-Vitro Only
96	2D6	panobinostat	under review
97	2C19	pantoprazole	Weak inhibitor
98	3A457	pantoprazole
99	2D6	paroxetine	Strong inhibitor
100	3A457	perampanel
101	2D6	perphenazine	In-Vitro Only
102	2C9	phenylbutazone	Moderate inhibitor
103	2D6	promethazine	under review
104	1A2	quercetin	Weak inhibitor
105	2C9	quercetin	Weak inhibitor
106	2C19	quercetin	In-Vitro Only
107	3A457	quercetin
108	2D6	quinidine	Strong inhibitor
109	3A457	regorafenib	under review
110	1A2	ribociclib	Weak inhibitor
111	3A457	ribociclib	Strong inhibitor
112	2D6	ritonavir
113	3A457	ritonavir	Strong inhibitor
114	2D6	rolapitant	Moderate inhibitor
115	3A457	rucaparib
116	3A457	saquinavir	Strong inhibitor
117	2D6	sertraline
118	1A2	simeprevir	Weak inhibitor
119	3A457	simeprevir
120	3A457	starfruit	under review
121	2C9	sulfamethoxazole	Weak inhibitor
122	2C9	sulfaphenazole	Strong inhibitor
123	3A457	telaprevir	under review
124	3A457	telithromycin	Strong inhibitor
125	2D6	terbinafine (oral)	Moderate inhibitor
126	3A457	ticagrelor
127	2C19	ticlopidine	Strong inhibitor
128	2D6	ticlopidine	In-Vitro Only
129	2C19	topiramate	under review
130	2D6	tripelennamine	In-Vitro Only
131	3A457	tucatinib	Strong inhibitor
132	1A2	vemurafenib	Moderate inhibitor
133	2D6	vemurafenib
134	3A457	verapamil	Moderate inhibitor
135	2C9	voriconazole	Weak inhibitor
136	2C19	voriconazole	Moderate inhibitor
137	3A457	voriconazole	Strong inhibitor
138	2C9	zafirlukast	Weak inhibitor

The follwing drugs will Increase effect by doxepin effect

#	enzyme	drug	level
1	2D6	alprenolol	Moderate inhibitor
2	2D6	amitriptyline	Moderate inhibitor
3	2D6	amphetamine	Moderate inhibitor
4	2D6	atomoxetine	Moderate inhibitor
5	2D6	brexpiprazole	Moderate inhibitor
6	2D6	bufuralol	Moderate inhibitor
7	2D6	cariprazine	Moderate inhibitor
8	2D6	carvedilol	Moderate inhibitor
9	2D6	chlorpheniramine	Moderate inhibitor
10	2D6	chlorpromazine	Moderate inhibitor
11	2D6	citalopram	Moderate inhibitor
12	2D6	clomipramine	Moderate inhibitor
13	2D6	clonidine	Moderate inhibitor
14	2D6	codeine	Moderate inhibitor
15	2D6	debrisoquine	Moderate inhibitor
16	2D6	desipramine	Moderate inhibitor
17	2D6	deutetrabenazine	Moderate inhibitor
18	2D6	dexfenfluramine	Moderate inhibitor
19	2D6	dextromethorphan	Moderate inhibitor
20	2D6	donepezil	Moderate inhibitor
21	2D6	doxepin	Moderate inhibitor
22	2D6	eliglustat	Moderate inhibitor
23	2D6	encainide	Moderate inhibitor
24	2D6	escitalopram	Moderate inhibitor
25	2D6	flecainide	Moderate inhibitor
26	2D6	fluoxetine	Moderate inhibitor
27	2D6	fluvoxamine	Moderate inhibitor
28	2D6	ibrutinib	Moderate inhibitor
29	2D6	imipramine	Moderate inhibitor
30	2D6	lidocaine	Moderate inhibitor
31	2D6	metoclopramide	Moderate inhibitor
32	2D6	metoprolol	Moderate inhibitor
33	2D6	mexiletine	Moderate inhibitor
34	2D6	minaprine	Moderate inhibitor
35	2D6	nebivolol	Moderate inhibitor
36	2D6	nortriptyline	Moderate inhibitor
37	2D6	ondansetron	Moderate inhibitor
38	2D6	oxycodone	Moderate inhibitor
39	2D6	paroxetine	Moderate inhibitor
40	2D6	perhexiline	Moderate inhibitor
41	2D6	perphenazine	Moderate inhibitor
42	2D6	phenacetin	Moderate inhibitor
43	2D6	pimavanserin	Moderate inhibitor
44	2D6	ponatinib	Moderate inhibitor
45	2D6	promethazine	Moderate inhibitor
46	2D6	propafenone	Moderate inhibitor
47	2D6	propranolol	Moderate inhibitor
48	2D6	risperidone	Moderate inhibitor
49	2D6	rucaparib	Moderate inhibitor
50	2D6	sparteine	Moderate inhibitor
51	2D6	tamoxifen	Moderate inhibitor
52	2D6	tetrabenzine	Moderate inhibitor
53	2D6	thioridazine	Moderate inhibitor
54	2D6	timolol	Moderate inhibitor
55	2D6	tramadol	Moderate inhibitor
56	2D6	umeclidinium	Moderate inhibitor
57	2D6	valbenazine	Moderate inhibitor
58	2D6	venlafaxine	Moderate inhibitor
59	2D6	vilazodone	Moderate inhibitor
60	2D6	zuclopenthixol	Moderate inhibitor

will decrease doxepin effect

#

enzyme

inducers

doxepin will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.