The following drugs will decrease disulfiram effect

#

enzyme

inducers

the follwing drugs will Increase disulfiram effect

#

enzyme

Inhibitors

level

The follwing drugs will Increase effect by disulfiram effect

#	enzyme	drug	level
1	2E1	acetaminophen	Strong inhibitor
2	2E1	aniline	Strong inhibitor
3	2E1	chlorzoxazone	Strong inhibitor
4	2E1	enflurane	Strong inhibitor
5	2E1	ethanol	Strong inhibitor
6	2E1	halothane	Strong inhibitor
7	2E1	isoflurane	Strong inhibitor
8	2E1	methoxyflurane	Strong inhibitor
9	2D6	metoclopramide
10	2D6	mexiletine
11	2D6	minaprine
12	2E1	n,n-dimethylformamide	Strong inhibitor
13	2D6	netupitant/palonosetron
14	2D6	nortriptyline
15	2D6	ondansetron
16	2D6	oxycodone
17	2D6	paroxetine
18	2D6	perhexiline
19	2D6	perphenazine
20	2D6	phenacetin
21	2D6	phenformin
22	2D6	pimavanserin
23	2D6	pomalidomide
24	2D6	ponatinib
25	2D6	promethazine
26	2D6	propafenone
27	2D6	propranolol
28	2D6	rucaparib
29	2E1	sevoflurane	Strong inhibitor
30	2D6	sparteine
31	2D6	tamoxifen
32	2D6	tetrabenzine
33	2E1	theophylline	Strong inhibitor
34	2D6	thioridazine
35	2D6	timolol
36	2D6	tramadol
37	2D6	umeclidinium
38	2D6	valbenazine
39	2D6	venlafaxine
40	2D6	vilazodone
41	2D6	zuclopenthixol

will decrease disulfiram effect

#

enzyme

inducers

disulfiram will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.