The following drugs will decrease diphenhydramine effect

#

enzyme

inducers

the follwing drugs will Increase diphenhydramine effect

#

enzyme

Inhibitors

level

The follwing drugs will Increase effect by diphenhydramine effect

#	enzyme	drug	level
1	2D6	alprenolol
2	2D6	amitriptyline
3	2D6	amphetamine
4	2D6	atomoxetine
5	2D6	brexpiprazole
6	2D6	bufuralol
7	2D6	cariprazine
8	2D6	carvedilol
9	2D6	chlorpheniramine
10	2D6	chlorpromazine
11	2D6	citalopram
12	2D6	clomipramine
13	2D6	clonidine
14	2D6	codeine
15	2D6	debrisoquine
16	2D6	desipramine
17	2D6	deutetrabenazine
18	2D6	dexfenfluramine
19	2D6	dextromethorphan
20	2D6	donepezil
21	2D6	doxepin
22	2D6	eliglustat
23	2D6	encainide
24	2D6	escitalopram
25	2D6	flecainide
26	2D6	fluoxetine
27	2D6	fluvoxamine
28	2D6	ibrutinib
29	2D6	imipramine
30	2D6	lidocaine
31	2D6	metoclopramide
32	2D6	metoprolol
33	2D6	mexiletine
34	2D6	minaprine
35	2D6	nebivolol
36	2D6	nortriptyline
37	2D6	ondansetron
38	2D6	oxycodone
39	2D6	paroxetine
40	2D6	perhexiline
41	2D6	perphenazine
42	2D6	phenacetin
43	2D6	pimavanserin
44	2D6	ponatinib
45	2D6	promethazine
46	2D6	propafenone
47	2D6	propranolol
48	2D6	risperidone
49	2D6	rucaparib
50	2D6	sparteine
51	2D6	tamoxifen
52	2D6	tetrabenzine
53	2D6	thioridazine
54	2D6	timolol
55	2D6	tramadol
56	2D6	umeclidinium
57	2D6	valbenazine
58	2D6	venlafaxine
59	2D6	vilazodone
60	2D6	zuclopenthixol

will decrease diphenhydramine effect

#

enzyme

inducers

diphenhydramine will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.