clomipramine
The following drugs will decrease clomipramine effect
# | enzyme | inducers |
0 | 1A2 | beta-naphthoflavone |
1 | 2C19 | carbamazepine |
2 | 2C19 | efavirenz |
3 | 1A2 | broccoli |
4 | 2C19 | enzalutamide |
5 | 1A2 | brussel sprouts |
6 | 1A2 | carbamazepine |
7 | 2C19 | letermovir |
8 | 1A2 | char-grilled meat |
9 | 2C19 | norethindrone |
10 | 2C19 | prednisone |
11 | 2C19 | rifampicin |
12 | 2C19 | ritonavir |
13 | 1A2 | insulin |
14 | 1A2 | methylcholanthrene |
15 | 1A2 | modafinil |
16 | 1A2 | nafcillin |
17 | 1A2 | omeprazole |
18 | 1A2 | rifampin |
19 | 1A2 | rucaparib |
20 | 1A2 | teriflunomide |
21 | 1A2 | tobacco |
the follwing drugs will
Increase clomipramine effect
# | enzyme | Inhibitors | level |
0 | 2D6 | abiraterone | Moderate inhibitor |
1 | 1A2 | amiodarone | |
2 | 2D6 | amiodarone | Weak inhibitor |
3 | 2C19 | armodafinil | Weak inhibitor |
4 | 2D6 | bupropion | Strong inhibitor |
5 | 2D6 | celecoxib | Weak inhibitor |
6 | 2C19 | chloramphenicol | In-Vitro Only |
7 | 2D6 | chlorpromazine | In-Vitro Only |
8 | 1A2 | cimetidine | Weak inhibitor |
9 | 2C19 | cimetidine | Weak inhibitor |
10 | 2D6 | cimetidine | Weak inhibitor |
11 | 2D6 | cinacalcet | Moderate inhibitor |
12 | 1A2 | ciprofloxacin | |
13 | 1A2 | citalopram | Weak inhibitor |
14 | 2C19 | citalopram | Weak inhibitor |
15 | 2D6 | citalopram | Weak inhibitor |
16 | 2D6 | clemastine | In-Vitro Only |
17 | 2D6 | clobazam | |
18 | 2D6 | clomipramine | |
19 | 2D6 | cocaine | In-Vitro Only |
20 | 2D6 | diphenhydramine | |
21 | 2D6 | doxepin | Moderate inhibitor |
22 | 2D6 | duloxetine | Moderate inhibitor |
23 | 1A2 | efavirenz | Weak inhibitor |
24 | 2D6 | escitalopram | |
25 | 2C19 | esomeprazole | Weak inhibitor |
26 | 2C19 | felbamate | Weak inhibitor |
27 | 2C19 | fluconazole | Moderate inhibitor |
28 | 2C19 | fluoxetine | Moderate inhibitor |
29 | 2D6 | fluoxetine | Strong inhibitor |
30 | 1A2 | fluvoxamine | Strong inhibitor |
31 | 2C19 | fluvoxamine | Strong inhibitor |
32 | 1A2 | furafylline | In-Vitro Only |
33 | 2D6 | halofantrine | Moderate inhibitor |
34 | 2D6 | haloperidol | In-Vitro Only |
35 | 2D6 | hydroxyzine | In-Vitro Only |
36 | 2C19 | isoniazid | Weak inhibitor |
37 | 2C19 | ketoconazole | Moderate inhibitor |
38 | 2D6 | levomepromazine | |
39 | 2D6 | lorcaserin | Moderate inhibitor |
40 | 2C19 | luliconazole | Weak inhibitor |
41 | 2D6 | methadone | under review |
42 | 1A2 | methoxsalen | In-Vitro Only |
43 | 2D6 | metoclopramide | In-Vitro Only |
44 | 2D6 | midodrine | |
45 | 2D6 | moclobemide | Moderate inhibitor |
46 | 2C19 | modafinil | Weak inhibitor |
47 | 2C19 | omeprazole | Weak inhibitor |
48 | 2C19 | oral contraceptives | Weak inhibitor |
49 | 2C19 | oritavancin | In-Vitro Only |
50 | 2D6 | panobinostat | under review |
51 | 2C19 | pantoprazole | Weak inhibitor |
52 | 2D6 | paroxetine | Strong inhibitor |
53 | 2D6 | perphenazine | In-Vitro Only |
54 | 2D6 | promethazine | under review |
55 | 1A2 | quercetin | Weak inhibitor |
56 | 2C19 | quercetin | In-Vitro Only |
57 | 2D6 | quinidine | Strong inhibitor |
58 | 1A2 | ribociclib | Weak inhibitor |
59 | 2D6 | ritonavir | |
60 | 2D6 | rolapitant | Moderate inhibitor |
61 | 2D6 | sertraline | |
62 | 1A2 | simeprevir | Weak inhibitor |
63 | 2D6 | terbinafine (oral) | Moderate inhibitor |
64 | 2C19 | ticlopidine | Strong inhibitor |
65 | 2D6 | ticlopidine | In-Vitro Only |
66 | 2C19 | topiramate | under review |
67 | 2D6 | tripelennamine | In-Vitro Only |
68 | 1A2 | vemurafenib | Moderate inhibitor |
69 | 2D6 | vemurafenib | |
70 | 2C19 | voriconazole | Moderate inhibitor |
The follwing drugs will Increase effect by clomipramine effect
# | enzyme | drug | level |
1 | 2D6 | alprenolol | |
2 | 2D6 | amitriptyline | |
3 | 2D6 | amphetamine | |
4 | 2D6 | atomoxetine | |
5 | 2D6 | brexpiprazole | |
6 | 2D6 | bufuralol | |
7 | 2D6 | cariprazine | |
8 | 2D6 | carvedilol | |
9 | 2D6 | chlorpheniramine | |
10 | 2D6 | chlorpromazine | |
11 | 2D6 | citalopram | |
12 | 2D6 | clomipramine | |
13 | 2D6 | clonidine | |
14 | 2D6 | codeine | |
15 | 2D6 | debrisoquine | |
16 | 2D6 | desipramine | |
17 | 2D6 | deutetrabenazine | |
18 | 2D6 | dexfenfluramine | |
19 | 2D6 | dextromethorphan | |
20 | 2D6 | donepezil | |
21 | 2D6 | doxepin | |
22 | 2D6 | eliglustat | |
23 | 2D6 | encainide | |
24 | 2D6 | escitalopram | |
25 | 2D6 | flecainide | |
26 | 2D6 | fluoxetine | |
27 | 2D6 | fluvoxamine | |
28 | 2D6 | ibrutinib | |
29 | 2D6 | imipramine | |
30 | 2D6 | lidocaine | |
31 | 2D6 | metoclopramide | |
32 | 2D6 | metoprolol | |
33 | 2D6 | mexiletine | |
34 | 2D6 | minaprine | |
35 | 2D6 | nebivolol | |
36 | 2D6 | nortriptyline | |
37 | 2D6 | ondansetron | |
38 | 2D6 | oxycodone | |
39 | 2D6 | paroxetine | |
40 | 2D6 | perhexiline | |
41 | 2D6 | perphenazine | |
42 | 2D6 | phenacetin | |
43 | 2D6 | pimavanserin | |
44 | 2D6 | ponatinib | |
45 | 2D6 | promethazine | |
46 | 2D6 | propafenone | |
47 | 2D6 | propranolol | |
48 | 2D6 | risperidone | |
49 | 2D6 | rucaparib | |
50 | 2D6 | sparteine | |
51 | 2D6 | tamoxifen | |
52 | 2D6 | tetrabenzine | |
53 | 2D6 | thioridazine | |
54 | 2D6 | timolol | |
55 | 2D6 | tramadol | |
56 | 2D6 | umeclidinium | |
57 | 2D6 | valbenazine | |
58 | 2D6 | venlafaxine | |
59 | 2D6 | vilazodone | |
60 | 2D6 | zuclopenthixol | |
will
decrease clomipramine effect
clomipramine will not affect
Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.