Welcome to the Deep Dive

This website is a comprehensive physiological review of hypertension, built from first principles. We start with the fundamental physics of blood flow and travel all the way down to the molecular machinery of vascular smooth muscle, the hormonal axes of the adrenal gland, and finally, a practical clinical guideline for assessment and management.

Use the navigation above to explore each topic in detail.

BP = CO × TPR Mean Arterial Pressure = Cardiac Output × Total Peripheral Resistance

🔬 What You Will Learn

How Stroke Volume and Heart Rate drive Cardiac Output.
The distinct roles of Arteries, Veins, and Capillaries.
Exactly how Calcium and the Na/K Pump control vessel diameter.
The pathophysiology of Adrenal Tumors (Pheochromocytoma, Conn's, Cushing's).
How to translate all this physiology into a clinical treatment algorithm.

🩺 Why This Matters

Hypertension is not a single disease; it is a symptom of a broken physiological gear. By understanding which gear is broken—whether it is high cardiac output, high vascular resistance, or high volume—you can predict exactly which medication will work and why. This is physiology-based, precision medicine.

Clinical Pearl High HR + High BP = Sympathetic drive. Normal HR + High BP = Vascular resistance.