CASPOFUNGIN ACETATE

Brand Name & Strength

Cancidas® 50 mg & 70 mg

Reconstitution

Reconstitute 50 mg vial with 10.5 ml of NS or WFI (5.2 mg/ml) Reconstitute 70 mg vial with 10.5 ml of NS or WFI (7.2 mg/ml)

Further Dilution

IV infusion

50 mg: Dilute reconstituted solution in a 100 ml intravenous bag or bottle

70 mg: Dilute reconstituted solution into two separate 100 ml intravenous bags or bottles (5 ml of reconstituted solution in each bag/bottle)

Pediatric patients (≥ 12 months old): Dilute reconstituted solution in a 250 ml intravenous bag or bottle not exceeding a final concentration of 0.5 mg/ml

Diluent

NS, lactated Ringer’s solution or ½NS (for pediatric patients)

Administration & Infusion rate

IV infusion

Administer slowly over 1 hr

For a 70 mg dose, administer each of the bags or bottles sequentially over 30 min

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

24 hr -

After dilution

24 hr 48 hr

Remarks

Do not use any diluents containing dextrose (α-D-glucose)

Do not mix or co-infuse with any other medications