about Miconazole class, uses, side effects contraindications
Miconazole
Short Description
Miconazole is an antifungal medication that has been popular since the 1970s and works by stopping the growth of the fungus causing the infection.
Common uses of miconazole
Miconazole is used to treat the following conditions:
Candida infection inside the mouth and throat.
Vulvovaginal candidiasis.
Tinea infection of the skin, such as: ringworm, tinea cruris, tinea pedis, and tinea versicolor.
Trade Name & Company Name
effect of Miconazole in Pregnancy, Fetal Health
and Breast feeding
Pregnancy
. Candida vaginitis is perhaps the most common female genital tract infection. The vaginal milieu during Pregnancy
predisposes to C. albicans overgrowth. There are no adequate reports or well- controlled studies of miconazole in pregnant women. There is controversy whether the various imidazole compounds differ in efficacy for mycotic vaginitis. Studies conducted immediately after miconazole was released suggested it was significantly better than nystatin, clotrimazole, and butoconazole for the treatment of vaginal candidiasis during gestation. However, no RCT substantiates that conclusion. There is no significant difference in cure rates achieved after 7-14d of therapy. Significantly more patients relapsed after cure in the nystatin and clotrimazole groups than in the miconazole groups. Miconazole is as effective 715 as oral therapy with fluconazole for vulvovaginal candidiasis. About 25-30% of the oral dose, but less than 0.1% of the vaginal dose, is absorbed. Though women frequently prefer oral medication, fluconazole is not recommended during pregnancy. Fetal Health
There are no adequate reports or well-controlled studies in human fetuses. It is unknown whether miconazole crosses the human placenta, but it has been used successfully in newborns. In vitro, miconazole effectively inhibits placental and fetal adrenal steroid aromatase. Miconazole is absorbed systemically after vaginal application, reaching peak levels approximating 10ng/ml. In contrast, parenteral levels of miconazole exceed mcg/ml. Post- marketing studies are reassuring, revealing no excess rates of adverse outcomes. Rodent studies are reassuring, revealing no evidence of teratogenicity or IUGR despite the use of doses higher than those used clinically. Embryotoxicity is associated with doses that also produce maternal toxicity. Breastfeeding
There is no published experience in nursing women. It is unknown whether miconazole enters human breast milk. However, considering the dose and route, it is unlikely the breastfed neonate of a woman being treated for vaginitis with vaginal applications would ingest clinically relevant amounts.
the follwing drugs will increse Miconazole by inhepiting cyp450
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the follwing drugs will decrease Miconazole by inhancing cyp450
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trad drugs based on Miconazole
| Gen name | Trade name | Catagory name |
| miconazole | Aloe Vesta | Topical antifungals |
| miconazole | Aloe Vesta 2 in 1 Antifungal | Topical antifungals |
| miconazole | Azolen | Topical antifungals |
| miconazole | Baza Antifungal | Topical antifungals |
| miconazole | Critic-Aid Clear AF | Topical antifungals |
| miconazole | Cruex Prescription Strength | Topical antifungals |
| miconazole | DermaFungal | Topical antifungals |
| miconazole | Dermagran AF | Topical antifungals |
| miconazole | Desenex Antifungal Atheletes Foot Spray Liquid | Topical antifungals |
| miconazole | Desenex Antifungal Foot Cream | Topical antifungals |
| miconazole | Desenex Jock Itch | Topical antifungals |
| miconazole | Fungoid | Topical antifungals |
| miconazole | Lotrimin AF Athlete's Foot Powder | Topical antifungals |
| miconazole | Lotrimin AF Deodorant Powder Spray | Topical antifungals |
| miconazole | Lotrimin AF Jock Itch Powder Spray | Topical antifungals |
| miconazole | M-Zole 3 | Topical antifungals |
| miconazole | Micaderm | Topical antifungals |
| miconazole | Micatin | Topical antifungals |
| miconazole | Micon 7 | Topical antifungals |
| miconazole | Micro-Guard | Topical antifungals |
| miconazole | Miranel AF | Topical antifungals |
| miconazole | Mitrazol | Topical antifungals |
| miconazole | Monistat-Derm | Topical antifungals |
| miconazole | NuZole | Topical antifungals |
| miconazole | Ony-Clear | Topical antifungals |
| miconazole | Secura Antifungal | Topical antifungals |
| miconazole | Secura Antifungal Extra Thick | Topical antifungals |
| miconazole | Soothe & Cool Inzo | Topical antifungals |
| miconazole | Tetterine | Topical antifungals |
| miconazole | Triple Paste AF | Topical antifungals |
| miconazole | Zeasorb-AF | Topical antifungals |
| miconazole | Zeasorb-AF Drying Gel | Topical antifungals |
| miconazole / zinc oxide | Rash Relief Antifungal | Topical antifungals |
| miconazole / zinc oxide | Vusion | Topical antifungals |
| Miconazole | CANDICORT CREAM | |
| Miconazole | CONAZOL 2% CREAM | |
| Miconazole | DAKTARIN CREAM 2% | |
| Miconazole | DAKTARIN ORALGEL 2% | |
| Miconazole | DAKTARIN POWDER 2% | |
| Miconazole | MICOCORT CREAM | |
| Miconazole | MIRAGEL 2% ORAL GEL | |
| Miconazole | MYCODERM 2% CREAM | |
| Miconazole | RESOLVE TINEA 2%CREAM | |
other drugs from same cataogory