about Alfuzosin class, uses, side effects contraindications

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Alfuzosin

Short Description

Alfuzosin is a drug belonging to the family of selective alpha blockers, which is used to treat symptoms of benign prostatic hyperplasia, which include difficulty and pain in urination and frequent need to urinate.
Alpha receptors contribute to smooth muscle contraction, and are widely distributed in the prostate gland and the neck of the urinary bladder. Inhibition of the receptors by alfuzosin allows the muscles of the bladder and prostate to relax, which improves urine flow and relieves symptoms of the disease.
The symptoms of adenoma in the prostate gland are similar to the symptoms?of prostate cancer?(prostatic cancer), so before starting treatment with Alfuzosin, the presence of a malignant tumor in the gland must be excluded.

Pregnancy category: B

Indications

To treat signs and symptoms of benign prostatic hyperplasia
Adults. 10 mg daily taken immediately after same meal each day.

Mechanism of Action

Selectively blocks alpha1-adrenergic receptors in smooth muscle of the bladder neck and prostate, causing relaxation, and blocks postsynaptic alpha1adrenoreceptors in the bladder base and neck, prostate, prostatic capsule, and urethra, preventing further action at these sites. These actions improve urine flow and bladder emptying and reduce urinary hesitancy, frequency, and nocturia.

Contraindications

Hypersensitivity to alfuzosin or its components, moderate or severe hepatic insufficiency, use with CYP3A4 inhibitors, such as itraconazole, ketoconazole, and ritonavir

Interactions

alpha blockers: May potentiate alfuzosin action antihypertensives, nitrates: Possibly synergistic lowering of blood pressure and syncope CYP3A4 inhibitors (such as itraconazole, ketoconazole, ritonavir): Increased alfuzosin effects

Side Efect

CNS: Dizziness, fatigue, headache
CV: Angina, chest pain, edema, orthostatic hypotension, QT-interval prolongation, tachycardia
EENT: Intraoperative floppy iris syndrome, pharyngitis, rhinitis, sinusitis
GI: Abdominal pain, constipation, diarrhea, indigestion, jaundice, hepatotoxicity, nausea
GU: Impotence, priapism
RESP: Bronchitis, upper respiratory tract infection
SKIN: Flushing, pruritus, rash, urticaria
Other: Angioedema, generalized pain

Cautions

Use alfuzosin cautiously in patients who have symptomatic hypotension or who have had a hypotensive response to other . Orthostatic hypotension (with or without symptoms such as dizziness) may occur within hours after alfuzosin administration.

Use cautiously in patients with severe renal insufficiency; decreased drug clearance may increase risk of adverse reactions.

Be aware that alfuzosin shouldn’t be used to treat bladder symptoms in women.

Know that alpha1blockers such as alfuzosin may predispose patients to intraoperative floppy iris syndrome during cataract surgery that may require surgical repair.

Monitor patient for chest pain. If symptoms of angina pectoris occur or worsen, notify prescriber immediately and expect drug to be discontinued.

PATIENT SAFTY

Stress need to take alfuzosin immediately after a meal because absorption is decreased by 50% if taken on an empty stomach.

Tell patient not to crush or chew tablets but to swallow them whole.

Caution patient to avoid hazardous activities until drug’s CNS effects are known and also for several hours after taking dose; blood pressure may drop suddenly after use.

Trade Name & Company Name

Trade name	Company name
XATRAL XL 10 MG	sanofi-aventis
XATRAL 2.5MG TAB	sanofi-aventis
XATRAL 5MG SRTAB	sanofi-aventis
URITAB XL 10MG EXTENDED RELEASE TABLETS	TABUK PHARMACEUTICAL MANUFACTURING CO.

effect of Alfuzosin in Pregnancy, Fetal Health and Breast feeding

the follwing drugs will increse Alfuzosin by inhepiting cyp450

No File found

the follwing drugs will decrease Alfuzosin by inhancing cyp450